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Formulation Guide

INGREDIENTS mg/Tablet
Ascorbic Acid 1000
Tartaric Acid 200
Sorbitol DC 200
Sodium Bicarbonate 172

Direct Compression

INGREDIENTS mg/Tablet
CBD Isolate 100
Ascorbic acid 250
Lactose DC 100
Crospovidone 20
Macrogol 6000 powder 3

Pass all components through a 0.8-mm sieve, mix, and press with medium-compression force.

INGREDIENTS mg/Tablet
CBD Isolate 100
Dextrose 500
PVP 90 4
Water 0
PEG-6000 (powder) 16

1. Granulate mixture of items 1 and 2 with solution of items 4 and 5 (in a fluidized bed), sieve, add item 6, and press with high-compression force.

2. Compress into 620-mg tablets, using 12-mm biplanar punches.

INGREDIENTS mg/Tablet
Thiamine Hydrocholoride 100
Lactose 200
Polyvinylpyrrolidone K 30 10
Crospovidone 9
Magnesium Stearate 2
Silicon Dioxide 1

INGREDIENTS mg/Tablet
Riboflavin 100
Sorbitol DC 250
Copovidone 19
Silicon Dioxide 10
Magnesium Stearate 5

INGREDIENTS mg/Tablet
Ascorbic Acid 110
Glucose Monohydrate 500
Polyvinylpyrrolidone K 90 4
Poloyethylene Glycol 6000 powder 6

INGREDIENTS mg/Tablet
Ascorbic Acid 105
Microcrystalline Cellulose 70
Sucrose, Ground 32
Sucrose, crystalline 20
Cyclamate, sodium salt 6
Polyethylene Glycol 6000 5
Orange Flavor 2
Strawberry Flavor 1
Silicon Dioxide 1
Saccharin 0

INGREDIENTS mg/Tablet
Beta-carotene 100
Ascorbic acid (crystalline) 250
Sodium ascorbate 280
Vitamin E acetate (dry powder, SD 50) 500
Sorbitol DC 600
Lactose DC 500
Fructose DC 350
PEG-6000 (powder) 50

1. Mix all components, pass through a sieve, and press with high-compression force.

2. The 20-mm biplanar tablet has an average weight of 2.6 g.

INGREDIENTS mg/Tablet
CBD Isolate 10
Sodium bicarbonate 198
Citric acid 100

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

INGREDIENTS mg/Tablet
CBD Isolate 10
Tartaric acid (fine crystals) 36
Sodium bicarbonatea 44
Saccharin sodium 20
Sodium chloride (milled) 2
Lime flavor 1
Sucrose DC 170

Mix items 1-8 in a V-blender and mix for 15 minutes. Compress at low forces.

INGREDIENTS mg/Tablet
CBD Isolate 10
Pharmaburst 181
Acesulfame K 3
Magnesium stearate 2
Talc (fine powder) 2
Dry mint flavor 3

1. Sift and mix items 1, 2, 3, and 6.

2. Lubricate with magnesium stearate and fine talc powder.

3. Compress into 200-mg tablets, using 6-mm punches.

INGREDIENTS mg/Tablet
CBD Isolate 112
Sorbitol DC 200
Anhydrous citric acid 1000
Sodium bicarbonate 587
PEG-6000 (powder) 65
Lemon flavor 10
Cyclamate sodium 25
Saccharin sodium 1

1. Dry the sodium bicarbonate for 1 hour at 100.C, mix with the other components, pass all through a 0.8-mm sieve,

INGREDIENTS mg/Tablet
CBD Isolate 12
Magnesium Trisilicate 25
Lactose Mono DC Grade 23
Aerosil R® 200 1
Magnesium Stearate 1
Cyclamate sodium 1
Menthol 2

Mix all components, pass through an 0.8-mm sieve, and press with a compression force of 20 kN.

INGREDIENTS mg/Tablet
CBD Isolate 13
Citric acid anhydrous 650
Sodium bicarbonate granular 367
Sodium carbonate anhydrous 40
Flavor 25
Color 5
Sodium benzoate 8
Water, purified 2

1. Premix the CBD granule with sodium bicarbonate and Sodium Benzoate. Mix the color with sodium carbonate. Place citric acid in a bowl of a suitable blender.

2. Slowly add 2 mg of water to the citric acid and mix thoroughly to form a moist blend. Add to the blend, in sequence, while mixing, the sodium bicarbonate mix and the sodium carbonate color mix. Mix until uniformly dis-tributed.

3. Compress tablets using suitably sized tooling. Cure the tablets, cool, and package in aluminum foil.

INGREDIENTS mg/Tablet
CBD Isolate 13
Microcrystalline Cellulose 160
Magnesium Stearate 2
Croscarmellose sodium type A 4

1. Pre-mix CBDC-75 with one-third quantity of the microcrystalline cellulose and one-half the quantity of the anhydrous lactose in a blender for 5 minutes at 20 rpm.

2. To the premix is added the remaining two-thirds of the microcrystalline cellulose and the remaining one-half of the anhydrous lactose. Blend for 10 minutes at 20 rpm.

3. Add croscarmellose sodium to the blended powders in step 2 and mix for 5 minutes at 20 rpm.

4. Add item 4 to the mixture after passing it through a 90-mesh screen and blend for an additional 5 minutes at 20 rpm.

5. Compress into 400 mg tablets, using a suitable punch.

INGREDIENTS mg/Tablet
CBD Isolate 13
Maize Starch 11
Mannitol, DC 105
Magnesium Stearate 1

A mixture containing CBDC-75, mannitol, maize starch, and microcrystalline cellulose is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 130 mg in the mas

INGREDIENTS mg/Tablet
Caffeine Powder 150
Microcrystalline Cellulose 36
Lactose DC 46
Di-Pac granular 49
Croscarmellose sodium (Ac-Di-Sol SD-711) 3
Silicon Dioxide 2
Stearic Acid 1
Magnesium Stearate 1
Flavor 1

1. Screen items 1, 7, and 8 separately through a 40-mesh sieve.

2. Blend items 1 to 6 and 9 in a V-shaped blender, and mix for 3 minutes.

3. Add item 8 to the blender and mix for another 5 minutes.

4. Compress, using 7 kg pressure and 3/8-in., flat, bevelededge punches to produce tablets with an average weight of 311 mg.

INGREDIENTS mg/Tablet
Beta-carotene 150
Calcium hydrogen phosphate granulated with 5% polyvinylpyrrolidone K 30 175
Microcrystalline Cellulose 100
Crospovidone 25
Talc 20
Silica 5
Calcium Arachinate 2

INGREDIENTS mg/Tablet
CBD Isolate 16
Microcrystalline Cellulose 101 50
Veegum F 10
Sodium starch glucolate 42.00 8
Magnesium stearate 2

1. Pass items 1 to 4 through a 250 mesh screen and blend for 10 minutes.

2. Add item 5, blend for 1 minute, and pass the mixture through a #11 sieve.

3. Compression at low compression force.

INGREDIENTS mg/Tablet
Nicotinamide 200
Microcrystalline Cellulose 100
Copovidone 10
Magnesium Stearate 2
Silicon Dioxide 2

INGREDIENTS mg/Tablet
Tocopheryl acetate dry powder 400
Lactose DC LCE 190
Silicon Dioxide 10

Tocopheryl acetate dry powder 50%, spray-dried with gelatin

INGREDIENTS mg/Tablet
Beta-carotene (dry powder, 10%) 20
Microcrystalline Cellulose 250
Kollidon R CL 20
Silicon dioxide 2

1. Mix all components, and press with a low-compression force.

2. Compress into 518-mg tablets, using 12-mm biplanar punches.

INGREDIENTS mg/Tablet
CBD Isolate 20
Sorbitol DC 10
Tartaric acid powder 14
Sodium carbonate 19
PVP K25 2
PEG 6000 powder 1

1. Mix all components and pass through a 0.5-mm sieve.

2. Press to tablets at 66 mg.

INGREDIENTS mg/Tablet
CBD Isolate 20
Lactose DC 133
Microcrystalline cellulose 102 40
Povidone 24
Fruit Punch Flavor 2
Magnesium stearate 2

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

INGREDIENTS mg/Tablet
CBD Isolate 20
Starch 1500 375
Microcrystalline Cellulose 102 328
Stearic Acid 15
Fumed Silica 6
Magnesium Stearate 2

1. Blend half of the Starch 1500 with the fumed silica and CBD Granulate for 5 minutes.

2. Pass this mixture through a 40-mesh screen and return to blender.

3. Add the remaining starch 1500 to the material in step 1 and blend for 5 additional minutes.

4. Add the microcrystalline cellulose (MCC 102) and stearic acid to the material from step 2 and blend for an additional 10 minutes.

5. Add the magnesium stearate to the material from step 3 and blend for an additional 5 minutes.

INGREDIENTS mg/Tablet
CBD Isolate 22
Sorbitol DC 150
Kollidon R® VA 64 5
Menthol (crystalline) 5
Eucalyptol (crystalline) 5
Aspartame, potassium 1
Saccharin sodium 0
Aerosil R® 200 2
Magnesium stearate 1

1. Mix all components, pass through an 0.8-mm sieve.

2. Compress into lozenge, using 8-mm biplanar punches.

INGREDIENTS mg/Tablet
CBD Isolate 24
Sodium bicarbonate 27
Citric acid anhydrous 27
Microcrystalline cellulose 10
Xylitol 10
Sucrose stearate 2

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

INGREDIENTS mg/Tablet
Calcium Pantothenate 275
Calcium hydrogen phosphate 150
Microcrystalline Cellulose 50
Crospovidone 20
Searic Acid 3
Magnesium Stearate 3

INGREDIENTS mg/Tablet
Activated charcoal 250
Bolus alba (Merck) 150
Kollidon 25 28
Acacia gum 38
Water + isopropanol (10 + 3) 575
Cremophor EL 15
Isopropanol 300

1. Granulate mixture of items 1 to 4 with item 5, and pass through a 1-mm sieve.

2. Dry until a relative powder humidity of 90% is reached.

3. Add solution of items 6 and 7, and pass again through a 0.8-mm sieve.

4. Dry the granules, and press into 481-mg tablets using lowcompression force and 12-mm planar punches

5. Dry the obtained tablets.

INGREDIENTS mg/Tablet
Sodium ascorbate granular 210
Ascorbic acid, powder 70
Lactose DC 195
Searic Acid 14
Orange Flavor 5
Silicon Dioxide 3

INGREDIENTS mg/Tablet
CBD Isolate 28
Lactose DC 225
Crospovidone 10
Magnesium Stearate 10

Mix all components, pass through a 0.5-mm sieve, and press with low compression force.

INGREDIENTS mg/Tablet
CBD Isolate 30
Lactose DC 100
Magnesium Stearate 2

1. Discharge all the ingredients through a 0.5-mm sieve, and mix for 10 minutes.

2. Press into 132-mg CBD tablets using medium-compression force and 8-mm biplanar punches.

INGREDIENTS mg/Tablet
CBD Isolate 30
Sorbitol DC 150
Microcrystalline Cellulose 140
Crospovidone 30
PEG-6000 (powder) 40
Orange Flavor 1

1. Pass all components through an 0.8-mm sieve, mix, and press with low-compression force.

2. Compress using 12-mm biplanar punches.

3. Crospovidone may be omitted and the tablet weight adjusted.

INGREDIENTS mg/Tablet
CBD Isolate 31
Sodium bicarbonate/tartaric acid (powder) 45
PVP K30 60
Sucrose (crystalline) 40
Crospovidone 20
PEG-6000 (powder) 6

Mix all ingredients for 15 minutes and compress al high forces.

INGREDIENTS mg/Tablet
Ascorbic Acid 375
Sodium Ascorbate 142
Viamin E 40
Lactose DC LCE 840
Polyethylene Glycol Powder 40
Orange Flavor 25
Mango Flavor 25
Aspartame 20

Direct Compression

INGREDIENTS mg/Tablet
CBD Isolate 40
Lactose anhydrous 312
Microcrystalline cellulose 240
Sodium carboxymethylcellulose 6
Magnesium stearate 3

CBDC-75 is first blended with one-third of microcrystalline cellulose 102 and with one-half of anhydrous lactose. The premixture obtained is then blended with both remaining excipients and it is mixed again. Sodium salt of carmellose is added under mixing to be followed with magnesium stearate to finish the mixture blending. When homogenized by forth mixing the mixture is subjected to the compression.

INGREDIENTS mg/Tablet
Ascorbic Acid 40
Starch 1500 58
Stearic Acid 2
Silicon dioxide 1

INGREDIENTS mg/Tablet
CBD Isolate 45
Gelatin Powder 175
Croscarmellose sodium 3
Talc 3
Magnesium Stearate 3

1. Add CBDC-75, gelatin, and croscarmellose sodium, one item at a time, in a suitable blender, and mix for 15 minutes.

2. Add talc and magnesium stearate, and mix for an additional 5 minutes.

3. Compress into 230-mg tablets, using 6-mm punches.

INGREDIENTS mg/Tablet
Sodium Bicarbonate 696
Tartaric Acid 594
Ascorbic Acid 450
Sorbitol DC 212
Granulated Sdium Ascorbate 106
Sodium Benzoate 83
PEG 6000 63
Orange Flavor 41
Sodium Saccharinate, ground 8

In a mixer, pour and mix for 5 minutes in 6 steps:

1. Tartaric acid and sodium bicarbonate

2. Ascorbic acid and sodium ascorbate

3. Sorbitol DC, flavor and sodium saccharinate

4. A third of PEG 6000 and sodium benzoate

5. A third of PEG 6000 and sodium benzoate

6. A third of PEG 6000 and sodium benzoate. The powder is ready to be compressed.

INGREDIENTS mg/Tablet
Ascorbic Acid 530
Sorbitol DC 50
Polyethlene Glycol 6000 37
Cyclamate 10

INGREDIENTS mg/Tablet
CBD Isolate 50
Sorbitol DC 85
Lactose (120 Mesh) 10
FD&C Yellow Dye No. 5 lake 3
Microcrystalline Cellulose 101 83
Silica Gel 12
Lemon Flavor 8
Starwberry Flavor 1
Sodium cyclamate 8
Magnesium Stearate 33

1. Pass CBDC-75 granulate, sodium ascorbate, sorbitol, lactose, FD&C Yellow Dye, microcrystalline cellulose, silica gel, flavors, and sodium cyclamate through a 420-mircrogram screen.

2. Using a comminuting mill, pass the coarse granules through a 420-microgm screen (knives forward, medium speed).

3. Transfer milled materials to a suitable blender, and blend for 5 minutes.

4. Screen the magnesium stearate by hand through an 840-microgm screen, and transfer to blender.

5. Mix for 1 minute.

6. Compress using 18-mm standard concave punches.

INGREDIENTS mg/Tablet
CBD Isolate 50
Dextrose 400
PVP 90 4
PEG-6000 (powder) 6

Pass all ingredients through a 0.8-mm sieve and press with high-compression force.

INGREDIENTS mg/Tablet
CBD Isolate 50
Lactose 346
Hydroxypropylmethylcellulose 2208 66
Magnesium stearate 3
Colloidal anhydrous silica 6
Talc 29

1. Mix all ingredients except 4 for 10 minutes.

2. Add Magnesium Stearate and mix for 1 minute.

3.  Compress using low compression forces.

INGREDIENTS mg/Tablet
Thiamine Hydrocholoride 55
Lactose DC 290
Magnesium Stearate 5
Silicon Dioxide 2

INGREDIENTS mg/Tablet
CBD Isolate 5
Sorbitol DC 150
Menthol (crystalline) 4
Eucalyptol (crystalline) 4
Aspartame, potassium 1
Saccharine sodium 0
Aerosil 200 1
Magnesium stearate 1

Mix all components, pass through an 0.8-mm sieve, and press with medium-compression force.

INGREDIENTS mg/Tablet
CBD Isolate 5
Mannitol DC 93
Gelatin 1
Aspartame 1
Colloidal silicon Dioxide 1

1. Pass item 2 through 0.7-mm sieve and collect in a stainless steel container.

2. Charge half quantity of step 1 in a tumbler.

3. Pass items 1 and items 3 to 5 through 0.5-mm sieve and collect in a container.

4. Add 15% Mannitol from step 1 to step 3 and mix well.

5. Compress at medium force.

INGREDIENTS mg/Tablet
Beta-carotene 70
Lactose DC 113
Anhydrous citric acid 200
Sodium bicarbonate 120
Sodium carbonate 12
Sodium cyclamate 20
Aspartame 15
Orange flavor 20
PEG-6000 (powder) 30

1. Pass all components through an 0.8-mm sieve and mix. Press with medium- or high-compression force at maximum 30% relative humidity.

3. Use 12-mm biplanar punches for 602-mg tablets.

INGREDIENTS mg/Tablet
CBD Isolate 8
Lactose Granular 24
Microcrystalline cellulose 101 40
Povidone 24
Sodium starch glycolate 22
Magnesium stearate 2

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

INGREDIENTS mg/Tablet
CBD Isolate 30
Sucrose, DC 60
Crospovidone XL 55
Orange Flavor 3
Strawberry Flavor 3
Microcrystalline Cellulose 102 155
Magnesium Stearate 1

Mix all items for 15 minutes, pass through a sieve, add Magnesium Stearate and mix for an additional 1 minute. Press with medium compression force.

INGREDIENTS mg/Tablet
CBD Isolate 100
Starch 1500 26
Microcrystalline Cellulose 21
Sodium Starch Glycolate 6

1. Blend all ingredients in a twin-shell blender for 10 minutes.

2. Compress into 153 mg tablets.

INGREDIENTS mg/Tablet
CBD Isolate 50
Lactose 200
Microcrystalline Cellulose 105
Magnesium Stearate 1

A mixture containing CBDC-75, Lactose, and Prosolv 50 is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 355mg tablets

INGREDIENTS mg/Tablet
CBD Isolate 90
Mannitol DC 246
Micrystalline Cellulose 30
Aspartame 9
Dyes 1
Citric Acid 1
Flavor 2
Magnesium Stearate 4

1. The CBDC-75 Granulate is coated with a layer of a taste-masking composition with a thickness of about 3 to 10 micrograms. The coating should be substantially free of cracks, holes, and other imperfections when examined under a scanning electron microscope at 100 to 500 magnification.

2. Charge items 1 to 7 in a suitable blender and mix for 20 minutes.

3. Add item 8 to step 2 and blend for 2 minutes.

4. Compress the appropriate quantity.

INGREDIENTS mg/Tablet
CBD Isolate 5
Lactose DC 100
Magnesium Stearate 2
Aerosil 200 1

1. Pass all components through an 0.8-mm sieve, mix, and press with very low-compression force (4 kN).

2. Compress into 202-mg tablets, using 8-mm biplanar punches.

3. This is a very low active ingredient formulation (5 mg), if content uniformity is a problem, prepare a premix of the active ingredient with a small part of the lactose monohydrate before mixing with the other components of the formulation.

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