How to make a Tablet Pill mix for a Press 4
PLEASE NOTE THAT WE NOW HAVE A MIX CALCULATOR IN OUR MEMBERS AREA WHICH IS FREE OF CHARGE FOR ANYBODY TO USE
Okay, so we're back at the table with the scales, and what we are going to do is we are going to weigh out our pure active ingredient tablets, which in this case is sugar. And as I was trying to tell you earlier, without the binding agent, you can see that they've actually come apart a little bit. The tops are coming apart. I've collected all the parts up so that we can get an accurate reading. And it was quite time consuming because the machine got jammed etc., etc. So I've only gone and done five. But again for a small run, five is more than enough to get an accurate reading so that we can calculate. And in the 5, they weigh 5.6 grams, which is fantastic because that means there's a massive difference between them and our binders, which will give us a really good example for the next part. So if you want to come back over to my whiteboard, I will show you what we have to do next.
Okay, so we're back on my whiteboard now and we have the average weight of the active ingredient tablets, which worked out to be 5.6 grams. So our active, rather than our binding, is 5.6 grams for 5 so we divide by 5. And that gives you an average tablet weight of 1.12. Now it might seem a little bit pedantic putting in those extra little digits, but it really works out for the best later on.
Now what we're going to do is we're going to say that we want 100 milligram dose of brown sugar inside our tablet. So, at the moment, we have 1.12 grams inside our tablet, and we want to be able to reduce that down to 100 milligrams. So the first thing we have to do is divide by 100 milligrams. We have to divide the gram by 100 milligrams, which is .01, and we'll tell you what that is now. So there is 11.2. The answer to that is 11.2. So what we have to do is we know now that there is 11.2 times too much active ingredient inside our tablet.
We're now going to take the binding, and we're going to divide it by 11.2, so that we can remove a big enough percentage of it to be able to fit in the 100 milligrams. So what we're going to do here is we're going to take this, and it's 0.585, and it's divided by 11.2, which gives us 0.052. So that's how much binding agent we need to remove from this mix to be able to fit in 100 milligrams of this. So if we now do 0.058 minus 0.052 so 0.0 . . . 0.585 minus 0.052, that gives us 0.533.
All right then. That means that in every tablet we now produce, we need 0.533 of our binding agent, and colors, and magnesium stearate, and 0.1 of our active ingredient. So that is our ratios that we now work to.
If you have to put in more than one active ingredient, for instance if you're doing a multivitamin pill and you're going to vitamin C and vitamin D, you would simply complete this step on the active ingredient, for every active ingredient you want in there, figuring out the quantity.
So this now gives us a very, very accurate estimation. Now if we want to make 10 tablets, we simply move the decimal point to here. So it would be 5.33 grams to 1 gram. If we wanted to make 100 tablets, we would move it two spaces over so it would be 53 grams of mix to 10 grams of active ingredient.
And what we're going to do tonight is we're actually going to make 100 tablets of our brown sugar. So we're going to move it two decimal places along, which means we need 53.3 grams of binding and color, and we need 10 grams of our brown sugar or active ingredient.
And if you join me back at the table, I will show you how to prepare a mix
To go back to part 3 click here