How to make a Tablet Pill mix for a Press 1
Whether or not it's a Handheld Tablet Press or one of the TDP Desktop Tablet Press Range, or even going all the way up to the Rotary Tablet Presses. This simple method can be applied to make sure that you get a very, very accurate mix of binder and active ingredient.
Choosing your ingredients
The first thing you need to do, is you need to construct a mix of your binders, your flowing, and your coloring agents. So right here, I have Microcrystalline Cellulose. I have tablet colouring in green, and I have Magnesium Stearate. And I'm going to be using these to construct my base powder for the production of my tablet. The magnesium stearate is really, really good at reducing moisture out of the air and out of the machine, and it keeps the powders flowing smoothly through the press. It also stops your dyes from jamming up.
Please also note that we no longer use Natrazol and have replaced it with LFA tablet mix colouring, which can be found in our Firmapress range.
The natrozol is green in this instance, but if you go onto the website, you can see we have a full range of colors. And it enables you to color your tablet. And the microcrystalline cellulose is a really, really good binding agent. And the ratios I have here are 30% and 70% on the natrozol to microcrystalline cellulose. And then, I add anywhere between two and ten percent on top of the other two, depending on how much moisture there is in the air or how prone your active ingredient is to absorbing moisture. So for instance, if you're working in a conservatory, the best thing to do would be bump it closer to ten percent. But if you're working in a dry, aired out area, or if you've got a dehumidifier in the room, then you can bring that percentage down closer to around two to four percent. The magnesium stearate, as well, is what gives tablets a really nice shine. So by just putting that little bit in there, you can do really great things.
Mixing the Ingredients
So the first thing I'm going to do, is I'm going to really properly get in and get all of these mixed together. We also sell the VH mixer series. So if you're doing anything more than a small batch like this, it's really quite useful to get one. They range in capacity from eight liters up to 500 liters, and they can mix that in about approximately eight to ten minutes. And I would estimate approximately a kilo per liter of capacity, but it's not quite that exact, due to density and other contributing factors. They are amazing, and they do make this job a hell of a lot easier if you've got orders of up to and over a couple of thousand kilos.
So there you can see, we've done a proper good mix on it. And the color's really taken very well to the microcrystalline and magnesium stearate. And next, we're going to move on to the next step of the process, which is calculating how much active ingredient we need to add to this to make a good mix so that when we produce our tablets, the right amount of active ingredient is in each tablet. Okay. So here's the mix I've just prepared, although it's only a small amount of it, with the magnesium stearate, the microcrystalline cellulose, and the natrozol color green. And I'm going to add a good bit of that into the chute of the press. And then, I am going to turn it on and let it do its magic.
All right, so there we go. We have a couple of tablets. And I'm just gonna go back to my scales now. We're going to weigh them out and we're going to calculate how much active ingredient we have to put in.