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A rapid mix granulator is a multi-purpose mixer/processor equally suitable for high speed dispersion of dry powders (including effervescent powders) and their granulation with aqueous or organic solvents. The equipment is designed to achieve rapid mixing and the formation of consistent granules required for the production of high quality pharmaceutical tablets for solid dosage forms of medication. Good mixing and control of granule size leads to fast tableting speeds and high quality products with low rejection rate.

The rules have changed when it comes to development of products in the pharmaceutical, health and nutritional industry. As generic and branded companies in the industry struggle with new products while at the same time addressing the need of new patients, the companies must also meet the growing productivity demands in the manufacturing industry.

A Mix–Up may be defined as:

• An unplanned combination of various compounds.
• A mistake brought about wrongly identifying one material for another.

A mix-up can be caused by bad judgement or lack of attention to detail, i.e., human error. It can also occur though poor communication between personnel.

The design of tablets requires careful research and understanding especially with respect to the shape of the tablets. Even tiny variations can have a direct impact not only on the cost of production but also on patient’s acceptance, which can lead to either the success or failure of the product.

Despite being an important part to the product’s success, the shape of the tablet is given less consideration by marketing departments and are only given much attention during a campaign where the shape and color of the tablet is promoted to the public. That said, small changes in the shape can impact the public’s acceptance as well as the tablet’s efficiency.

A single station tablet press is a simple mechanical machine that can be used to compress powder into tablets that are uniform in size, shape and weight. The machine is used for low-volume production of tablets for a wide range of applications from cosmetics and pharmaceuticals to cleaning products.

Capsules are popular and commonly used in the pharmaceutical industry, not only is it easy to manufacturer but it do not need any complex formulation unlike other drug containers.

Tablet binders are one of the most essential elements in the formulation of a tablet. Because they promote cohesiveness, the binders, also called adhesives, help the other ingredients in a tablet to mix together. Tablet binders are used to turn powder to granules; this is achieved through the process of granulation. During granulation, powder substances are accumulated to form larger particles called granules.

Definition: The term is used when either the upper or lower part of the tablet separates horizontally either partially away from the main body or completely and forms a cap when ejected from the press or during the handling process.

Cause: This happens when air is trapped during the compression stage and when the tablet expands after being ejected from the die.

The following is a brief operating and cleaning guide that can be used for most tablet de-dusting machines. It covers pre-start up, operation and cleaning, and lists some precautions that can be taken to help avoid contamination issues.

Here is a list of commonly used terms and there definitions. This it to help you understand and navigate our website more easily. We hope you find it useful.

If there is something that you feel needs adding to the list then please feel free to get in contact and we will add it.

Poor environmental control, particularly in terms of air humidity can directly affect the pharmaceutical production line in a number of ways. Levels of humidity below 45%RH will allow electrostatic charges to build up in machinery and materials.

Even the simplest form of pharmaceutical manufacturing process can involve a range of process steps before the product is packaged and shipped to the consumer.These may include:

Granulation is the process whereby powder forms are bound together to form aggregates, which are called as granules. Granulation is important as it helps prevent the separation of the ingredients in the mixture as well as improves the flow of the properties of the mixture. It also changes the size of the particles resulting to improved compression and density of the powder mix.

At LFA over the last 7 years we have seen a glimpse into every type of use for a tablet press. Nowadays when someone asks us how to press glass, or metal, or even coffee granules we are no longer surprised. One that was new to us was the pigeon problem.