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Overview Of Lyophilization Of Pharmaceutical Products

Overview Of Lyophilization Of Pharmaceutical Products

There are different products that are classified as parenteral and as some are unstable in solution form, they are being lyophilized. The process helps increase the shelf life of these products. In this article we look at how to best achieve this.

Maintaining Buffer Areas In Sterile Facilities

Maintaining Buffer Areas In Sterile Facilities

The buffer area is the space or area in the manufacturing facility where sterility of the area is strictly implemented. A compounding area in a pharmaceutical facility is known as the buffer area and is classified as ISO 7 area or class 10,000 with excellent air quality.

Making Tablets - The Right Tools for the job

Making Tablets - The Right Tools for the job

The concept of producing a tablet form dosage starts first at the company’s marketing department. With that said, the formulators are responsible in producing the said tablet. Below are some key points to consider when specifying the dies and press punches.

Multiple Station Tablet Rotary Press

Multiple Station Tablet Rotary Press

There are 2 types of tablet presses: single-punch and rotary tablet presses. Most high speed tablet presses take the form of a rotating turret that holds any number of punches and dies. As they rotate around the turret, the punches come into contact with cams which control the vertical position of each punch. Tablets produced by a rotary tablet press are compressed into uniform size, shape and weight making it the preferred machine for large-scale manufacture as it also produces more tablets than single punch machines.

Octagonal Blender – Operation and Cleaning Guide

Octagonal Blender – Operation and Cleaning Guide

A quick guide to learning how to operate and clean the Octagonal Blender used in the tablet manufacturing industry.

An Overview of Disintegrants

An Overview of Disintegrants

药品活性成分被人体吸收的能力取决于它的生物利用率。而生物利用度取决于药品通过肠道时,活性成分在消化液中的溶解程度。而溶解程度取决于药品的物理形态和化学成分。药片的崩解能力关系到它在体液内的溶解程度。对于大多数片剂而言,需要打破压片过程所致的颗粒凝聚力才能有效崩解。在压片之前,某些片剂产品为了将粉料结合而加入粘合剂,那么它们的崩解过程将比较困难。还有一些片剂的活性成分包裹在不能崩解的外壳内,以防止活性成分接触胃液,让药片溶解的过程难上加难。为确保片剂在人体内的分解速度足够快,每制作一批片剂前,都需要对配方进行一次例行测试。 

崩散剂片剂配方胶囊中的一种赋形剂。它提升片剂或胶囊接触液体时的崩解能力。多年来广泛应用的崩散剂有多种,它们的作用机制各不相同:(a)提升毛血管作用力,从而加强吸水能力(b)遇水后膨胀促进药片崩解(c)释放气体直接加快片剂的崩解。在产品配方中加入一种或多种崩散剂是为了提升产品的表面积,减弱固体微粒之间的凝聚力。这样起到的效果是,当片剂接触水媒介时,先崩解成颗粒,然后崩解成微粒。如图所示,片剂或胶囊在水媒介中的溶解率随着颗粒变小而上升,当片剂或胶囊崩解成微粒时,溶解率达到最高。1.快速溶解提升活性成分在人体内的吸收率,从而得到期望的治疗效果。需注意,咀嚼式的片剂产品不需要再配方中加入崩解剂。

An Overview of Vegetarian Capsules

An Overview of Vegetarian Capsules

The advancement in science and technology makes it easier for one to make their own supplements. Vegetarian capsules are healthier as these are derived from natural ingredients such as cellulose, hydroxyl and methyl. If you are looking for a healthy and natural alternative to traditional capsules, then vegetarian capsules can be an excellent choice for you.

how a tdp 5 grew a supplement company

Oxford Vitality - The Birth & Growth Of A Supplement Company

Over the years at LFA Tablet Presses we have seen our fair share of supplement companies but one of our biggest success by far is Oxford Vitality.

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Pharmaceutical User Requirement Specification Of Equipment

Pharmaceutical User Requirement Specification Of Equipment

The URS or User Requirement Specification is a document that contains buyer’s requirements concerning the equipment that they would like to purchase. The Equipment User Department prepares the URS and then sends it to the equipment manufacturer to follow. There are some points to consider when making the URS for pharmaceutical companies.

How To Prepare A Batch Manufacturing Record Template

How To Prepare A Batch Manufacturing Record Template

Batch manufacturing record or BMR is a document that contains the batch manufacturing details including the entire manufacturing process. As there are several stages in the manufacturing process, these are recorded as proof of the process from receiving the raw materials up to the final phases of packing. The proof and the documents are then attached to the BMR during the manufacturing process.

Different Preservatives And Concentration Dosage For Pharmaceutical Liquid Preparation

Different Preservatives And Concentration Dosage For Pharmaceutical Liquid Preparation

With a bigger move towards clean label LFA is seeing less and less use of chemicals in its customers products. Sometimes though it is impossible not to have to use a preservative when undertaking wet granulation.

Preventing Cross Contamination In Pharmaceutical Production Process

Preventing Cross Contamination In Pharmaceutical Production Process

There are several ways to prevent cross contamination during production and below are some ways to do so. Before starting, line clearance should be performed as per the SOP of the company. Do a checklist and record. Check to see if any starting materials are missing, previous record documents, product residues and product itself. Practice a closed system when handling the materials.

Procedure for Moving Desktop Tablet Presses

Procedure for Moving Desktop Tablet Presses

1) Ensure that anyone moving the press is wearing the correct protective clothing. This may include:

  • Steel toe boots
  • Heavy duty grip gloves
  • Back support belt
Procedures To Follow During In Process, Off-line and On-line Packing

Procedures To Follow During In Process, Off-line and On-line Packing

In this short article we state the guidelines to follow during the online and offline packing for pharmaceutical companies.

Process For Gowning – Entry And Exit Change Rooms

Process For Gowning – Entry And Exit Change Rooms

To prevent any contamination to the processing area or inside the building, it is important to learn the procedure for changing clothes during entry and exit through the company’s changing areas.

Color-coding can identify the personnel and their department. Color-coding for the first change room and primary change room is as indicated below:

Production – Standard Operating Procedures

Production – Standard Operating Procedures

A standard operating procedure (SOP) is a written instruction describing how a routine task is to be carried out; when, where and by whom. SOPs play a fundamental role in continuous quality assurance and ensuring best practice for your company, in order to assist you in protecting the safety of your patients and members of the public. The implementation of SOPs, which are specific to your production facility, will help you to:

How To Protect Light Sensitive Products

How To Protect Light Sensitive Products

It is crucial that pharmaceutical companies protect their light sensitive products from direct sunlight or certain spectrums of artificial light. One way to protect it is to use brown colored light especially during manufacturing.

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