Formulation Guide

INGREDIENTSmg/Tablet
Crospovidone, micronized1000
Citric Acid150
Silicon dioxide25
Sucrose, crystalline100
Saccharin sodium1
Water0
Magnesium stearate5
Sodium bicarbonate125
Flavour mixture65

1. Mix crospovidone, citric acid, and silicon dioxide.

2. Mix sucrose, saccharin sodium, and water.

3. Granulate crospovidone mixture with sucrose solution, then pass through a 20 mesh screen.

4. Mix magnesium stearate, sodium bicarbonate, and flavour mixture.

5. Mix magnesium stearate mixture with dry granulated mixture.

6. Compress into 1590mg tablets with 20mm bisect tooling.

INGREDIENTSmg/Tablet
Ascorbic Acid1000
Tartaric Acid200
Sorbitol DC200
Sodium Bicarbonate172

Direct Compression

INGREDIENTSmg/Tablet
Aminophylline powder100
Microcrystalline Cellulose200
Copovidone6
Magnesium stearate2
Silicon dioxide12

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 318mg tablets with 12mm bisect tooling.

Note: Due to the poor flowability of the powder the tabletting machine should be equipped with force feeder.

INGREDIENTSmg/Tablet
Aminophylline powder100
Ludipress�150
Silicon dioxide2
Magnesium stearate2

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 254mg tablets with 8mm bisect tooling.

Note: Long term compatibility between aminophylline and lactose should be controlled.

INGREDIENTSmg/Tablet
Ascorbic acid powder42
Sucrose (ground)13
Sucrose (crystalline)8
Microcrystalline cellulose28
Copovidone2
Polyethylene glycol (PEG) 6000 powder2
Flavoring Aroma1
Cyclamate Sodium2
Saccharin sodium0
Silicon dioxide0

INGREDIENTSmg/Tablet
CBD Isolate100
Dextrose500
PVP 904
Water0
PEG-6000 (powder)16

1. Granulate mixture of items 1 and 2 with solution of items 4 and 5 (in a fluidized bed), sieve, add item 6, and press with high-compression force.

2. Compress into 620-mg tablets, using 12-mm biplanar punches.

INGREDIENTSmg/Tablet
CBD Isolate100
Ascorbic acid250
Lactose DC100
Crospovidone20
Macrogol 6000 powder3

Pass all components through a 0.8-mm sieve, mix, and press with medium-compression force.

INGREDIENTSmg/Tablet
CBD Isolate100
Starch 150026
Microcrystalline Cellulose21
Sodium Starch Glycolate6

1. Blend all ingredients in a twin-shell blender for 10 minutes.

2. Compress into 153 mg tablets.

INGREDIENTSmg/Tablet
Ascorbic acid USP (fine crystal)28
Sodium Ascorbate USP82
Microcrystalline Cellulose39
Sodium saccharin (powder) N.F.1
Sucrose DC66
Stearic acid N.F.6
Imitation orange juice flavor2
FD&C Yellow No. 6 dye1
CAB-O-SIL® (Hydrophobic fumed silica)1

1. Blend all ingredients, except stearic acid, for 20 minutes.

2. Screen in the stearic acid and blend for an additional 5 minutes.

Note: It is not possible to make chewable ascorbic acid tablets with over 50% active ingredient. Other directly compressible sugars such as EMDEX® could be used to replace Sucrose, DC. Magnesium stearate should be avoided in ascorbic acid formulations. Addition of a higher concentration of MCC will not usually increase tablet hardness.

INGREDIENTSmg/Tablet
Choline theophyllinate100
Ludipress�244
Magnesium stearate6

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components.

4. Compress into 350mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Dimenhydrinate100
Lactose monohydrate40
Corn starch40
Povidone (PVP K90)6
Isopropanol30
Crospovidone14
Talc16
Silicon dioxide2
Calcium arachnicate2

1. Mix dimenhydrinate, lactose monohydrate, corn starch, and povidone.

2. Granulate dimenhydrinate mixture with isopropanol

3. Dry granulated mixture then pass through a 20 mesh sieve.

4. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

5. Mix crospovidone mixture with dry granulated mixture.

6. Compress into 210mg tablets with 9mm bisect convex tooling.

INGREDIENTSmg/Tablet
Dicalcium phosphate95
Lactose Monohydrate94
Povidone (PVP K30)9
Water25
Dried garlic powder100
Magnesium stearate2

1. Mix lactose monohydrate and dicalcium phosphate.

2. Mix povidone and water.

3. Granulate lactose mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen.

5. Mix dried garlic powder and magnesium stearate.

6. Add garlic powder mixture to granulated mixture.

7. Compress into 312mg tablets with 9mm bisect convex tooling.

INGREDIENTSmg/Tablet
Mebendazol100
Ludipress�196
Magnesium stearate4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 294mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Methyl cysteine hydrochloride100
Ludipress�200
Magnesium stearate3
Menthol4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 307mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Thiamine hydrochloride USP100
Microcrystalline Cellulose83
Lactose N.F. anhydrous142
Magnesium stearate N.F.7
CAB-O-SIL® (Hydrophobic fumed silica)2

1. Blend all ingredients, except magnesium stearate, for 25 minutes.

2. Screen in magnesium stearate and blend for an additional 5 minutes.

Note: Anhydrous lactose could be replaced with Fast Flo® lactose with no loss in tablet quality. This would reduce the need for a glidant.

INGREDIENTSmg/Tablet
Thiamine Hydrocholoride100
Lactose200
Polyvinylpyrrolidone K 3010
Crospovidone9
Magnesium Stearate2
Silicon Dioxide1

INGREDIENTSmg/Tablet
Riboflavin100
Sorbitol DC250
Copovidone19
Silicon Dioxide10
Magnesium Stearate5

INGREDIENTSmg/Tablet
Ascorbic Acid110
Glucose Monohydrate500
Polyvinylpyrrolidone K 904
Poloyethylene Glycol 6000 powder6

INGREDIENTSmg/Tablet
Ascorbic Acid105
Microcrystalline Cellulose70
Sucrose, Ground32
Sucrose, crystalline20
Cyclamate, sodium salt6
Polyethylene Glycol 60005
Orange Flavor2
Strawberry Flavor1
Silicon Dioxide1
Saccharin0

INGREDIENTSmg/Tablet
Amitryptylline10
Ludipress�139
Magnesium stearate1

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 152mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene100
Ascorbic acid (crystalline)250
Sodium ascorbate280
Vitamin E acetate (dry powder, SD 50)500
Sorbitol DC600
Lactose DC500
Fructose DC350
PEG-6000 (powder)50

1. Mix all components, pass through a sieve, and press with high-compression force.

2. The 20-mm biplanar tablet has an average weight of 2.6 g.

INGREDIENTSmg/Tablet
CBD Isolate10
Sodium bicarbonate198
Citric acid100

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

INGREDIENTSmg/Tablet
CBD Isolate10
Tartaric acid (fine crystals)36
Sodium bicarbonatea44
Saccharin sodium20
Sodium chloride (milled)2
Lime flavor1
Sucrose DC170

Mix items 1-8 in a V-blender and mix for 15 minutes. Compress at low forces.

INGREDIENTSmg/Tablet
CBD Isolate10
Pharmaburst181
Acesulfame K3
Magnesium stearate2
Talc (fine powder)2
Dry mint flavor3

1. Sift and mix items 1, 2, 3, and 6.

2. Lubricate with magnesium stearate and fine talc powder.

3. Compress into 200-mg tablets, using 6-mm punches.

INGREDIENTSmg/Tablet
Loratadine10
Microcrystalline Cellulose44
AEROSIL® 200 hydrophilic fumed silica3
Magnesium Stearate3
PVP K-303
Purified Talc5
Mannitol50
Aspartame0
Crospovidone30
Starch51

1. Mix starch and loratadine to form a uniform mixture

2. Mix remaining excipients (mannitol, aspartame, microcrystalline cellulose, colloidal silicon dioxide, purified talc, magnesium stearate, PVPK-30, sodium starch glycolate) step wise to the uniform mixture of powder.

INGREDIENTSmg/Tablet
Metoclopramide hydrochloride10
Ludipress�90
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 100mg tablets with 6mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate112
Sorbitol DC200
Anhydrous citric acid1000
Sodium bicarbonate587
PEG-6000 (powder)65
Lemon flavor10
Cyclamate sodium25
Saccharin sodium1

1. Dry the sodium bicarbonate for 1 hour at 100.C, mix with the other components, pass all through a 0.8-mm sieve,

INGREDIENTSmg/Tablet
Fucidine125
Dicalcium phosphate63
Povidone (PVP K90)3
Isopropanol30
Crospovidone6
Silicon dioxide1
Magnesium stearate3

1. Mix fucidine and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate fucidine mixture with povidone solution.

4. Dry then pass through a 20 mesh screen.

5. Mix crospovidone, silicon dioxide, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 200mg tablets with 9mm bisect convex tooling.

Note: To accelerate the disintegration rate, the amount of povidone should be reduced and add crospovidone whould be added in intra- extrgranular form.

INGREDIENTSmg/Tablet
Amoxicillin125
Corn starch148
Povidone (PVP K30)9
Water60
Crospovidone15
Magnesium stearate3

1. Mix amoxicillin and corn starch.

2. Mix povidone and water.

3. Wet granulate amoxicillin mixture with povidone solution.

4. Dry the granulated mixture then pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 297mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Griseofulvin, micronized125
Ludipress�250
Polyethylene glycol (PEG) 6000 powder10
Silicon dioxide19

1. Pass all components through a 35 mesh sieve.

2. Mix sieved components.

3. Compress into 267mg tablets with 12mm bisect tooling.

Note: To improve flowability of mixture, increase the amount of silicon dioxide or Ludipress�.

INGREDIENTSmg/Tablet
CBD Isolate12
Magnesium Trisilicate25
Lactose Mono DC Grade23
Aerosil R® 2001
Magnesium Stearate1
Cyclamate sodium1
Menthol2

Mix all components, pass through an 0.8-mm sieve, and press with a compression force of 20 kN.

INGREDIENTSmg/Tablet
CBD Isolate13
Citric acid anhydrous650
Sodium bicarbonate granular367
Sodium carbonate anhydrous40
Flavor25
Color5
Sodium benzoate8
Water, purified2

1. Premix the CBD granule with sodium bicarbonate and Sodium Benzoate. Mix the color with sodium carbonate. Place citric acid in a bowl of a suitable blender.

2. Slowly add 2 mg of water to the citric acid and mix thoroughly to form a moist blend. Add to the blend, in sequence, while mixing, the sodium bicarbonate mix and the sodium carbonate color mix. Mix until uniformly dis-tributed.

3. Compress tablets using suitably sized tooling. Cure the tablets, cool, and package in aluminum foil.

INGREDIENTSmg/Tablet
CBD Isolate13
Microcrystalline Cellulose160
Magnesium Stearate2
Croscarmellose sodium type A4

1. Pre-mix CBDC-75 with one-third quantity of the microcrystalline cellulose and one-half the quantity of the anhydrous lactose in a blender for 5 minutes at 20 rpm.

2. To the premix is added the remaining two-thirds of the microcrystalline cellulose and the remaining one-half of the anhydrous lactose. Blend for 10 minutes at 20 rpm.

3. Add croscarmellose sodium to the blended powders in step 2 and mix for 5 minutes at 20 rpm.

4. Add item 4 to the mixture after passing it through a 90-mesh screen and blend for an additional 5 minutes at 20 rpm.

5. Compress into 400 mg tablets, using a suitable punch.

INGREDIENTSmg/Tablet
CBD Isolate13
Maize Starch11
Mannitol, DC105
Magnesium Stearate1

A mixture containing CBDC-75, mannitol, maize starch, and microcrystalline cellulose is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 130 mg in the mas

INGREDIENTSmg/Tablet
Caffeine salicylate150
Gum Base300
Sorbitol350
Lecithin150
Flavor (L –menthol)10
Mannitol50
Magnesium Stearate10
Aerosil® fumed silica10
Sweetner (Sodium Saccharin)10

1.Gum base powder and active ingredient (Caffeine salicylate) are mixed well in mortar.

2. Soy lecithin, sorbitol, mannitol, sweetner, and L-menthol are added to gum base and active mix

3.After thorough mixing, add lubricant and glidant.

INGREDIENTSmg/Tablet
Caffeine Powder150
Microcrystalline Cellulose36
Lactose DC46
Sucrose DC49
Croscarmellose sodium (Ac-Di-Sol SD-711)3
Silicon Dioxide2
Stearic Acid1
Magnesium Stearate1
Flavor1

1. Screen items 1, 7, and 8 separately through a 40-mesh sieve.

2. Blend items 1 to 6 and 9 in a V-shaped blender, and mix for 3 minutes.

3. Add item 8 to the blender and mix for another 5 minutes.

4. Compress, using 7 kg pressure and 3/8-in., flat, bevelededge punches to produce tablets with an average weight of 311 mg.

INGREDIENTSmg/Tablet
Beta-carotene150
Calcium hydrogen phosphate granulated with 5% polyvinylpyrrolidone K 30175
Microcrystalline Cellulose100
Crospovidone25
Talc20
Silica5
Calcium Arachinate2

INGREDIENTSmg/Tablet
Beta-carotene dry powder 10%150
Dicalcium phosphate175
Povidone (PVP K30)9
Microcrystalline cellulose100
Crospovidone5
Silicon dioxide3
Talc20
Calcium arachinate3

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 502mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate16
Microcrystalline Cellulose 10150
Veegum F10
Sodium starch glucolate 42.008
Magnesium stearate2

1. Pass items 1 to 4 through a 250 mesh screen and blend for 10 minutes.

2. Add item 5, blend for 1 minute, and pass the mixture through a #11 sieve.

3. Compression at low compression force.

INGREDIENTSmg/Tablet
Peumus boldus (Dry Plant Extract)170
Microcrystalline Cellulose112
Lactose112
Magnesium Stearate6

1. Blend Dry plant extract and excipients, except magnesium stearate, for 12 minutes by tumbling.

2. Add corresponding amount of magnesium stearate and blended for another 4minutes.

3. Compress for 5 seconds.

INGREDIENTSmg/Tablet
Sodium fluoride2
EMDEX® (Starch-derived Glucose Monohydrate and Different Polysaccharides)106
Artificial grape flavor 5.5.0
Color. grape S31860
Magnesium stearate1

1. Mix ingredient sodium flouride and one-third of EMDEX® for 10 minutes.

2. Add remaining amount of EMDEX® and color and mix thoroughly for 20 minutes.

3. Add grape flvor and blend for 10 minutes.

4. Add magnesium stearate, blend 5 additional minutes, and compress.

INGREDIENTSmg/Tablet
Caffeine200
Microcrystalline Cellulose128
Dicalcium Phosphate42
Magnesium Stearate5

INGREDIENTSmg/Tablet
Calcium glycerophosphate200
Ludipress�298
Magnesium stearate3
Silicon dioxide0

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 470mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Carbamazepine200
Ludipress�300
Magnesium stearate2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 496mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Cimetidine200
Ludipress�295
Magnesium stearate5

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 510mg tablets with12mm bisect tooling.

INGREDIENTSmg/Tablet
Ferrous fumarate200
Ludipress�295
Magnesium stearate5

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 509mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Ferrous sulfate, anhydrous203
Ludipress�185
Copovidone15
Magnesium stearate4
Talc4
Silicon dioxide3

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 413mg tablets with 10mm bisect tooling.

INGREDIENTSmg/Tablet
Furosemide200
Lactose Monohydrate388
Magnesium stearate6
Silicon dioxide6

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 618mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Metronidazole200
Microcrystalline Cellulose200
Povidone (PVP K30)6
Crospovidone10
Silicon dioxide5
Magnesium stearate5

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 426mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Nicotinamide200
Microcrystalline Cellulose100
Copovidone10
Magnesium Stearate2
Silicon Dioxide2

INGREDIENTSmg/Tablet
Ascorbic Acid, Crystalline200
Polyvinyl Acetate + Povidone K30, 8:2, Spray dried200
Magnesium Stearate9

INGREDIENTSmg/Tablet
Tocopheryl acetate dry powder400
Lactose DC LCE190
Silicon Dioxide10

Tocopheryl acetate dry powder 50%, spray-dried with gelatin

INGREDIENTSmg/Tablet
Aspartame20
Sorbitol, crystalline10
Tartaric acid, powder14
Sodium bicarbonate19
Povidone (PVP K25)2
Polyethylene glycol 6000 powder1

1. Mix all components.

2. Pass through a 35 mesh sieve.

3. Compress into 66mg tablets with 6mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene dry powder 10%220
Microcrystalline cellulose250
Crospovidone20
Silicon dioxide2

1. Mix all components.

2. Compress into 518mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene (dry powder, 10%)20
Microcrystalline Cellulose250
Kollidon R CL20
Silicon dioxide2

1. Mix all components, and press with a low-compression force.

2. Compress into 518-mg tablets, using 12-mm biplanar punches.

INGREDIENTSmg/Tablet
CBD Isolate20
Sorbitol DC10
Tartaric acid powder14
Sodium carbonate19
PVP K252
PEG 6000 powder1

1. Mix all components and pass through a 0.5-mm sieve.

2. Press to tablets at 66 mg.

INGREDIENTSmg/Tablet
CBD Isolate20
Lactose DC133
Microcrystalline cellulose 10240
Povidone24
Fruit Punch Flavor2
Magnesium stearate2

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

INGREDIENTSmg/Tablet
CBD Isolate20
Starch 1500375
Microcrystalline Cellulose 102328
Stearic Acid15
Fumed Silica6
Magnesium Stearate2

1. Blend half of the Starch 1500 with the fumed silica and CBD Granulate for 5 minutes.

2. Pass this mixture through a 40-mesh screen and return to blender.

3. Add the remaining starch 1500 to the material in step 1 and blend for 5 additional minutes.

4. Add the microcrystalline cellulose (MCC 102) and stearic acid to the material from step 2 and blend for an additional 10 minutes.

5. Add the magnesium stearate to the material from step 3 and blend for an additional 5 minutes.

INGREDIENTSmg/Tablet
Curcumin20
Xanthan Gum10
Sodium Starch Glycolate12
Dicalcium Phosphate24
Microcrystalline Cellulose84

1. Prepare with wet granulation method, using 9% PEG (Polyethylene glycol) 6000 as lubricant, polyvinylpyrrolidone 5% as binder, mannitol as filler, 1% sodium chloride as glidant and 2% sodium lauryl sulphate as lubricant.
INGREDIENTSmg/Tablet
CBD Isolate22
Sorbitol DC150
Kollidon R® VA 645
Menthol (crystalline)5
Eucalyptol (crystalline)5
Aspartame, potassium1
Saccharin sodium0
Aerosil R® 2002
Magnesium stearate1

1. Mix all components, pass through an 0.8-mm sieve.

2. Compress into lozenge, using 8-mm biplanar punches.

INGREDIENTSmg/Tablet
CBD Isolate24
Sodium bicarbonate27
Citric acid anhydrous27
Microcrystalline cellulose10
Xylitol10
Sucrose stearate2

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

INGREDIENTSmg/Tablet
Alpha-Methyldopa250
Ludipress�350
Stearic acid15

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 620mg tablets with 11mm standard convex bisect tooling.

INGREDIENTSmg/Tablet
Alpha-Methyldopa275
Dicalcium phosphate55
Povidone (PVP K30)15
Isopropanol80
Crospovidone8
Magnesium stearate2

1. Mix alpha-methyldopa with dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate alpha-methyldopa mixture with povidone solution.

4. Pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with the dry granulated mixture.

7. Compress into 362mg tablets with 11mm biscect tooling.

INGREDIENTSmg/Tablet
Aluminium acetylsalicylate255
Mannitol213
Corn starch28
Povidone (PVP K90)10
Lutrol� E 60005
Isopropanol50
Crospovidone23
Magnesium Stearate5

1. Mix aluminum acetylsalicylate, mannitol, and corn starch.

2. Mix povidone, Lutrol® E 6000, and isopropanol.

3. Granulate aluminum acetylsalicylate with povidone solution.

4. Dry the granulated mixture then pass through a 20 mesh sieve.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 540mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Amoxicillin Trihydrate250
Health in Gum® PWD-01800
Menthol10
Aspartame5
AEROSIL® fumed silica7
Talc10
Titanium Dioxide5
Microcrystalline Cellulose13

1. Mix Amoxicillin Trihydrate, Health in Gum® PWD-01, and Menthol in porcelain mortar.

2.Pass through 100# sieve

3.Mix blend with AEROSIL® fumed silica, Talc, and Aspartame for 5 minutes.

4.Keep in freeze for 30 minutes.

INGREDIENTSmg/Tablet
Ampicillin trihydrate250
Ludipress�250
Magnesium stearate10

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

4. Compress into 500mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Ascorbic acid USP (fine crystal or granular)250
Microcrystalline Cellulose84
Starch 150076
Stearic acid N.F. (powder) or Sterotex®9
CAB-O-SIL® (Hydrophobic fumed silica)2

1. Blend all the ingredients, except stearic acid for 25 minutes.

2. Screen in stearic acid and blend for an additional 5 minutes.

Note: It is important to use free-flowing types of ascorbic acid due to the high concentration in the formulation. Ascorbic acid concentration could be increased slightly by using more MCC and less Starch 1500. Stearic acid, Sterotex®, Compritol 888®, and Lubritab® are interchangeable in most formulations.

INGREDIENTSmg/Tablet
Bran wheat (milled <1 mm)250
Ludipress�200
Silicon dioxide4
Magnesium stearate4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 477mg tablets with 12mm bisect tooling.

Note: If the bran is not milled, the hardness of tablet is higher but the content uniformity is less.

INGREDIENTSmg/Tablet
Bran wheat (milled <1 mm)250
Dicalcium phosphate200
Povidone (PVP K90)12
Water3
Polyethylene glycol 6000 powder0
Magnesium stearate4

1. Mix milled bran wheat and dicalsium phosphate.

2. Mix povidone with water.

2. Wet granulate milled bran wheat mix with povidone solution.

3. Pass mixture through a 20 mesh sieve.

4. Mix polyethylene glycol 6000 powder with magnesium stearate.

5. Mix polyethylene glycol 6000 mix with granulated mixture.

6. Compress into 467mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Calcium Pantothenate275
Calcium hydrogen phosphate150
Microcrystalline Cellulose50
Crospovidone20
Searic Acid3
Magnesium Stearate3

INGREDIENTSmg/Tablet
Calcium lactate650
Calcium gluconate625
Calcium carbonate190
Sodium bicarbonate410
Tartaric acid480
Povidone (PVP K30)60
Isopropanol0
Crospovidone100
Polyethylene glycol 6000 powder48
Flavour0

1. Mix calcium lactate, calcium gluconate, calcium carbonate, sodium bicarbonate, tartic acid, and 48g povidone.

2. Mix 12g povidone with Isopropanol.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, polyethylene glycol 6000 powder, and flavour.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 2500mg tablets with 22mm bisect tooling.

INGREDIENTSmg/Tablet
Activated charcoal250
Bolus alba (Merck)150
Kollidon 2528
Acacia gum38
Water + isopropanol (10 + 3)575
Cremophor EL15
Isopropanol300

1. Granulate mixture of items 1 to 4 with item 5, and pass through a 1-mm sieve.

2. Dry until a relative powder humidity of 90% is reached.

3. Add solution of items 6 and 7, and pass again through a 0.8-mm sieve.

4. Dry the granules, and press into 481-mg tablets using lowcompression force and 12-mm planar punches

5. Dry the obtained tablets.

INGREDIENTSmg/Tablet
Chloroquine diphosphate250
Dicalcium phosphate100
Povidone (PVP K30)10
Isopropanol83
Crospovidone10
Silicon dioxide2
Talc3

1. Mix chloroquine diphosphate and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate chloroquine diphosphate mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, silicon dioxide, and talc.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 361mg tablets with 9mm bisect tooling.

INGREDIENTSmg/Tablet
Mefenamic acid250
Corn starch40
Povidone (PVP K90)5
Isopropanol0
Crospovidone12
Microcrystalline Cellulose85
Magnesium stearate5

1. Mix mefenamic acid and cornstarch.

2. Mix povidone and isopropanol.

3. Granulate mefenamic acid mixture with povidone solution.

4. Sieve granulted mixture and dry.

5. Mix crospovidone, microcrystalline cellulose, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 404mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Rhodiola rosea L. extract (1.0% salidroside and 3.0% rosavin)250
Microcrystalline Cellulose500
Crospovidone

Add crospovidone (6.4% w/w) as a disintegrant.
INGREDIENTSmg/Tablet
Sodium ascorbate granular210
Ascorbic acid, powder70
Lactose DC195
Searic Acid14
Orange Flavor5
Silicon Dioxide3

INGREDIENTSmg/Tablet
Amitryptylline25
Ludipress�124
Magnesium stearate1

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 157mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Aspartame27
Ludipress�76
Magnesium stearate1
Lutrol� F-683

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 120mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Aspartame25
Dicalcium phosphate25
Copovidone3
Water10
Crospovidone3
Polyethylene glycol 6000 powder3

1. Mix aspartame, dicalcium phosphate, and copovidone.

2. Wet granulate aspartame mixure with water.

3. Pass mixture through a 20 mesh sieve

4. Mix crospovidone and Polyethylene glycol 6000 powder.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 60mg tablets with 5mm bisect tooling.

INGREDIENTSmg/Tablet
Catopril25
Ludipress�91
Crospovidone2
Magnesium Stearate2

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 122mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Khellin25
Ludipress�124
Magnesium stearate1

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 150mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Pyrilamine maleate USP25
Microcrystalline Cellulose34
Lactose N.F . Anhydrous137
Ac-Di-Sol® (Croscarmellose Sodium)2
CAB-O-SIL® (Hydrophobic fumed silica)1
Stearic acid (powder) N. F.1
Magnesium stearate N.F.1

1. Screen pyrilamine maleate, stearic acid, and magnesium stearate through 40 mesh sieve.

2. Blend pyrilamine maleate and lactose for 3 minutes in V blender.

3. Add microcrystalline cellilose, AcDiSol, and CAB-O-SIL® to step 2 and blend for 17 minutes.

4. Add stearic acid to step 3 and blend for 3 minutes.

5. Add magnesium stearate to step 4 and blend for 5 minutes.

INGREDIENTSmg/Tablet
Magnesium carbonate USP262
Ludipress�238
Magnesium stearate4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 499mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Chymotrypsine28
Ludipress�72
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh mm sieve.

3. Compress into 100mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Cimetidine288
Corn starch122
Povidone (PVP K30)14
Water72
Magnesium stearate2

1. Mix cimetidine and corn starch.

2. Mix povidone and water.

3. Granulate cimetidine mixture with povidone solution, then pass through a 20 mesh screen.

4. Add magnesium stearate.

5. Compress into 427mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate28
Lactose DC225
Crospovidone10
Magnesium Stearate10

Mix all components, pass through a 0.5-mm sieve, and press with low compression force.

INGREDIENTSmg/Tablet
Pharmagum� M85
Nicotine polacrilex2
Magnesium stearate2
Sorbitol8
Sodium carbonate3

INGREDIENTSmg/Tablet
Low Caffeine Instant Coffee1
Maltodextrin0
Citric Acid1
Sodium bicarbonate1
Coffee Natural Essence0
Fortified Calcium Concentrate0

1. Mix citric acid with low caffeine instant coffee and calcium.

2. Mix sodium bicarbonate with maltodextrin and natural coffee essences.

3. Before compression, mix materials in room temperature of 20? and 20% of relative humidity in order to ensure that environment does not affect water content in the materials.

Note: Drying process was conducted at 50? to minimize water content in the material and was conducted before mixing.

INGREDIENTSmg/Tablet
Allopurinol USP300
Firmaoil200
Sodium Starch Glycolate21
Talc10
CAB-O-SIL® (Hydrophobic fumed silica)3
Magnesium stearate N.F.5

1. Blend allopurinol and Firmaoil for 10 minutes.

2. Add sodium starch glycolate and blend for 10 more minutes.

3. Add talc and CAB-O-SIL® and blend for 3- 5 minutes.

4. Add magnesium stearate and blend 5 more minutes.

INGREDIENTSmg/Tablet
Ginger Dry Extract300
Polyvinylpyrrolidone17
Magnesium Aluminometasilicate5
Isomalt172
Calcium Stearate5

INGREDIENTSmg/Tablet
CBD Isolate30
Lactose DC100
Magnesium Stearate2

1. Discharge all the ingredients through a 0.5-mm sieve, and mix for 10 minutes.

2. Press into 132-mg CBD tablets using medium-compression force and 8-mm biplanar punches.

INGREDIENTSmg/Tablet
CBD Isolate30
Sorbitol DC150
Microcrystalline Cellulose140
Crospovidone30
PEG-6000 (powder)40
Orange Flavor1

1. Pass all components through an 0.8-mm sieve, mix, and press with low-compression force.

2. Compress using 12-mm biplanar punches.

3. Crospovidone may be omitted and the tablet weight adjusted.

INGREDIENTSmg/Tablet
Curcumin30
PVP (Polyvinylpyrrolidone)20
Xanthan Gum20
Microcrystalline Cellulose132

INGREDIENTSmg/Tablet
CBD Isolate31
Sodium bicarbonate/tartaric acid (powder)45
PVP K3060
Sucrose (crystalline)40
Crospovidone20
PEG-6000 (powder)6

Mix all ingredients for 15 minutes and compress al high forces.

INGREDIENTSmg/Tablet
Acetaminophen USP granular325
Solka Floc BW 100 (Powdered Cellulose)120
Microcrystalline Cellulose108
CAB-O-SIL® (Hydrophobic fumed silica)3
Explotab® (Sodium Starch Glycolate)14
Magnesium stearate N.F.4

1. Mix acetaminophen, Solka Floc-BW 100, and Emcocel together for 10 minutes.

2. Add CAB-O-SIL® and Explotab®, blend for 10 minutes.

3. Add magnesium stearate, and blend for 5 minutes. and compress at maximum compression force.

Note: Harder tablets can be made by replacing additional portions of Solka Floc with Emcocel.

INGREDIENTSmg/Tablet
Aspirin. USP (40 mesh)325
Microcrystalline Cellulose48
Cornstarch N.F.32

INGREDIENTSmg/Tablet
Calcium gluconate, powder360
Lactose monohydrate117
Povidone (PVP K30)11
Isopropanol90
Crospovidone25
Magnesium stearate2

1. Mix calcium gluconate and lactose monhydrate.

2. Mix 11g povidone with isopropanol.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 500mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Ascorbic Acid375
Sodium Ascorbate142
Viamin E40
Lactose DC LCE840
Polyethylene Glycol Powder40
Orange Flavor25
Mango Flavor25
Aspartame20

Direct Compression

INGREDIENTSmg/Tablet
Dicalcium phosphate400
Wheaten flour100
Citric acid crystalline1
Lactose monohydrate272
Flavours0
Povidone (PVP K90)20
Magnesium stearate4

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 800mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Ground Cinnamon100
Lactose Powder290
Sodium Sachrine2
Talc4
Magnesium Stearate4

1. Weigh all excipients and pass through 20 mesh sieve individually.

2. Mix ground cinnamon, lactose, and sodium sachrine with geometric mixing method for 15 minutes.

3. Add talc and magnesium stearate; mix thoroughly.

Note: Mannitol can be used in place of lactose in the same amount.

INGREDIENTSmg/Tablet
Ground Clove100
Lactose Powder290
Sodium Sachrine2
Talc4
Magnesium Stearate4

1. Weigh all excipients and pass through 20 mesh sieve individually.

2. Mix ground clove, lactose, and sodium sachrine with geometric mixing method for 15 minutes.

3. Add talc and magnesium stearate; mix thoroughly.

Note: Mannitol can be used in place of lactose in the same amount.

INGREDIENTSmg/Tablet
Ethambutol400
Sorbitol, crystalline200
Copovidone20
Crospovidone10
Magnesium stearate10

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 620mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Ethambutol800
Dicalcium phosphate200
Povidone (PVP K30)30
Isopropanol0
Crospovidone50
Magnesium stearate15

1. Mix ethambutol and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate ethambutol mixture with povidone solution, Dry the mixture then pass through a 20 mesh sieve.

4. Mix crospovidone and magnesium stearate.

5. Mix crospovidone mixture with dry granulated mixture.

6. Compress into 1112mg tablets with 20mm oblong tooling.

INGREDIENTSmg/Tablet
Ibuprofen (50 grade)400
Silicon dioxide6
Microcrystalline Cellulose79
Copovidone27
Crospovidone18
Magnesium stearate3

1. Mix ibuprofen with silicon dioxide.

2. Add remaining components.

3. Compress into 533mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Mannitol330
Povidone (PVP K30)12
Water0
Ibuprofen400
Crospovidone16
Silicon dioxide8
Magnesium stearate8

1. Mix povidone with water.

2. Granulate mannitol with povidone solution, then pass through a 20 mesh screen.

3. Mix ibuprofen, crospovidone, silicon dioxide, and magnesium stearate.

4. Addibuprofen mixture to granulated mixture.

5. Compress into 774mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Metronidazole400
Microcrystalline Cellulose150
Copovidone25
Crospovidone15
Silicon dioxide5
Polyethylene glycol (PEG) 6000 powder50

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 645mg tablets with 12mm bisect convex tooling.

INGREDIENTSmg/Tablet
CBD Isolate40
Lactose anhydrous312
Microcrystalline cellulose240
Sodium carboxymethylcellulose6
Magnesium stearate3

CBDC-75 is first blended with one-third of microcrystalline cellulose 102 and with one-half of anhydrous lactose. The premixture obtained is then blended with both remaining excipients and it is mixed again. Sodium salt of carmellose is added under mixing to be followed with magnesium stearate to finish the mixture blending. When homogenized by forth mixing the mixture is subjected to the compression.

INGREDIENTSmg/Tablet
Famotidine40
Ludipress�105
Magnesium stearate3
Silicon dioxide4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 149mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Furosemide USP40
Microcrystalline Cellulose19
Ac-Di-Sol® (Croscarmellose Sodium)2
Fast-Flo Lactose (Spray-dried Crystalline and Amorphous Lactose)95
Cab-O-Sil (Hydrophobic fumed silica)1
Stearic acid N.F.2
Magnesium stearate N.F.1

1. Screen CAB-O-SIL® through a 2O mesh sieve.

2. Screen stearic acid and magnesium stearate through a 40 mesh sieve.

3. Blend furosemide, microcrystalline cellulose, and lactose in V blender without intensifier bar for 1 minute and then blend with aid of intensifier bar for 30 seconds and without intensifier bar for 1.5 minutes.

4. Add croscarmellose and hydrophobic fumed silica, blend for 3 minutes.

5. Add stearic acid and blend for 3 minutes.

6. Add magnesium stearate and blend for 5 minutes.

7. Discharge blender and pass blend through 40 mesh sieve using oscillating granulator.

8. Charge blender with sieved blend and blend for 5 minutes.

INGREDIENTSmg/Tablet
Furosemide40
Ludipress�158
Magnesium stearate2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 205mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Ascorbic Acid40
Starch 150058
Stearic Acid2
Silicon dioxide1

INGREDIENTSmg/Tablet
Powdered Herb250
Lactose DC10
Microcrystalline Cellulose30
Magnesium Stearate5
Talc5

INGREDIENTSmg/Tablet
Horsetail extract, powder456
Copovidone14
Lutrol� F-685
Isopropanol0
Crospovidone14
Magnesium stearate0

1. Mix copovidone, Lutrol, and isopropanol .

2. Granulate horsetail extract powder with copovidone solution..

3. Dry then pass through a 20 mesh screen.

4. Mix crospovidone with magnesium stearate.

5. Mix crospovidone mix with granulated mix.

6. Compress into 489mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate45
Gelatin Powder175
Croscarmellose sodium3
Talc3
Magnesium Stearate3

1. Add CBDC-75, gelatin, and croscarmellose sodium, one item at a time, in a suitable blender, and mix for 15 minutes.

2. Add talc and magnesium stearate, and mix for an additional 5 minutes.

3. Compress into 230-mg tablets, using 6-mm punches.

INGREDIENTSmg/Tablet
Cyproheptadine4
Ludipress�194
Magnesium stearate2

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 202mg tablets with 8mm bisect tooling.

Note: If the content uniformity does not meet the requirements it would be recommended to prepare a premix of the active ingredient with a small part of the Ludipress� or with lactose monohydrate before mixing with the other components of the formulation.

INGREDIENTSmg/Tablet
Ondansetron Hydrochloride4
Sodium Starch Glycolate2
Croscarmellose Sodium2
Mannitol9
Microcrystalline Cellulose58
Sodium Saccharine0
Mint Flavor2
AEROSIL® Fumed Silica1
Magnesium Stearate0

Pass Mannitol, Sodium Starch Glycolate, and Croscarmellose Sodium were through a 100 mesh screen prior to mixing.

Mix Ondansetron Hydrochloride to sieved blend of powder.

Add and mix mint Flavor, Aerosil®, and Magnesium Stearate

INGREDIENTSmg/Tablet
Alpha-Methyldopa500
Microcrystalline cellulose 10154
Copovidone20
Crospovidone20
Talc90
Silicon dioxide7
Magnesium stearate2

1. Pass magnesium stearate trough a 70 mesh sieve.

2. Pass remaining components through 35 mesh sieve.

3. Blend sieved magnsium stearate with remaining sieved components.

4. Compress into 750mg tablets with 12mm bisect tooling.

Note: Capping likelihood is increased with convex tooling.

INGREDIENTSmg/Tablet
Alpha-Methyldopa500
Lactose monohydrate200
Povidone (PVP K30)30
Isopropanol35
Crospovidone20
Silicon dioxide5
Magnesium stearate8

1. Mix alpha-methyldopa and lactose monohydrate.

2. Mix povidone and isopropanol.

3. Granulate alpha-methyldopa mixtures with povidone solution, then pass through a 20 mesh sieve.

4. Mix crospovidone, silicon dioxide, and magnesium stearate.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 540mg tablets with 12mm bisect tooling.

Note: Oblong tooling is recommended for tablet cores that are to be coated.

INGREDIENTSmg/Tablet
Ampicillin trihydrate500
Sorbitol, crystalline242
Copovidone25
Isopropanol or water0
Crospovidone12
Magnesium stearate10
Silicon dioxide8

1. Mix ampicillin trihydrate and sorbitol.

2. Mix copovidone with isopropanol or water.

3. Wet granulate ampicillin mixture with copovidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, magnesium stearate, and silicon dioxide.

6. Mix crospovidone mixture with granulated mixture.

7. Compress 822mg tablets with 16mm bisect tooling.

INGREDIENTSmg/Tablet
Ashwagandha powder500
Lactose Powder108
Crospovidone108
Camphor24
Magnesium Stearate6
Talc6

1. Mix ashwagandha powder, excipients, crospovidone, and camphor in a plastic container.

2. After compressing the tablets, vacuum driy at 60? until a constant weight was obtained.

INGREDIENTSmg/Tablet
Calcium glycerophosphate500
Corn starch118
Povidone (PVP K90)15
Water60
Crospovidone15
Magnesium stearate3

1. Mix calcium glycerophosphate and corn starch.

2. Mix povidone with water.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 650mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Griseofulvin500
Copovidone100
Dimethyl formamide7500
Crospovidone75
Lactose monohydrate75
Magnesium stearate5
Silicon dioxide5

1. Mix griseofulvin and copovidone.

2. Dissolve griseofulvin mixture in dimethyl formamide.

3. Evaporate to dryness and pass through a 35 mesh screen.

4. Mix crospovidone, lactose monohydrate, magnesium stearate, and silicon dioxide.

5. Mix crospovidone mix with granulated mix.

6. Compress into 751mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Magaldrate USP500
Lactose Monohydrate400
Orange flavor50
Povidone (PVP K90)20
Banana flavour6
Cocos flavour6
Saccharin sodium1
Water180
Silicon dioxide5
Magnesium stearate3

1. Mix magaldrate, lactose monohydrate, and orange flavour.

2. Mix povidone, banana flavour, cocos flavour, saccharin sodium, and water.

3. Granulate magaldrate mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen then dry.

5. Mix silicon dioxide and magnesium stearate.

6. Add silicon dioxide mixture to granulated mixture.

7. Compress into 1000mg tablets with 16mm bisect tooling.

INGREDIENTSmg/Tablet
Metamizol sodium500
Ludipress�100
Crospovidone10
Magnesium stearate10
Silicon dioxide5

1. Mix all components.

2. Pass through a 35 mesh sieve.

3. Compress into 499mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Metformin hydrochloride500
Dicalcium phosphate100
Povidone (PVP K90)23
Isopropanol90
Crospovidone5
Polyethylene glycol (PEG) 6000 powder15

1. Mix metformin hydrochloride, dicalcium phosphate, and 15g povidone.

2. Mix 8g copovidone and 90g isopropanol.

3. Granulate metformin hydrochloride mixture with copovidone solution.

4. Mix crospovidone with PEG 6000 powder.

5. Mix crospovidone mixture into granulated mixture, then pass through a 20 mesh sieve.

6. Compress into 650mg tablets with 12mm bisect tooling.

Note: Reduce the amount of povidone if tablets are too hard.

INGREDIENTSmg/Tablet
Metronidazole500
Sorbitol, crystalline220
Povidonr (PVP K90)10
Ethanol 96%0
Crospovidone20
Talc4
Silicon dioxide1
Calcium arachinate1

1. Mix metronidazole and sorbitol.

2. Mix povidone and ethanol.

3. Granulate metronidazole mixture with povidone solution.

4. Pass through 20 mesh sieve and dry.

5. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

6. Mix crospovidone mixture into granulated mixture.

7. Compress into 755mg tablets with 16mm bisect tooling.

INGREDIENTSmg/Tablet
Whole milk powder275
Microcrystalline Cellulose75
Povidone20
Sucrose75
Talc50
Magnesium Stearate5

1. Mix all ingredients except magnesium stearate thoroughly using double cone blender for 15 minutes. Set the speed of the blender to 35 revolutions per minute.

2. Compress mixed excipients into a 10mm slug or tablets using a rotary tableting press.

3. Crush slug into small granules using an oscillating granulator. The granules produced will be used for final compression.

4. Add magnesium stearate to the formulation granules and mix again using double cone blender at 35 revolutions per minute for 15 minutes.

INGREDIENTSmg/Tablet
Sodium Bicarbonate696
Tartaric Acid594
Ascorbic Acid450
Sorbitol DC212
Granulated Sdium Ascorbate106
Sodium Benzoate83
PEG 600063
Orange Flavor41
Sodium Saccharinate, ground8

In a mixer, pour and mix for 5 minutes in 6 steps:

1. Tartaric acid and sodium bicarbonate

2. Ascorbic acid and sodium ascorbate

3. Sorbitol DC, flavor and sodium saccharinate

4. A third of PEG 6000 and sodium benzoate

5. A third of PEG 6000 and sodium benzoate

6. A third of PEG 6000 and sodium benzoate. The powder is ready to be compressed.

INGREDIENTSmg/Tablet
Ascorbic Acid530
Sorbitol DC50
Polyethlene Glycol 600037
Cyclamate10

INGREDIENTSmg/Tablet
CBD Isolate50
Sorbitol DC85
Lactose (120 Mesh)10
FD&C Yellow Dye No. 5 lake3
Microcrystalline Cellulose 10183
Silica Gel12
Lemon Flavor8
Starwberry Flavor1
Sodium cyclamate8
Magnesium Stearate33

1. Pass CBDC-75 granulate, sodium ascorbate, sorbitol, lactose, FD&C Yellow Dye, microcrystalline cellulose, silica gel, flavors, and sodium cyclamate through a 420-mircrogram screen.

2. Using a comminuting mill, pass the coarse granules through a 420-microgm screen (knives forward, medium speed).

3. Transfer milled materials to a suitable blender, and blend for 5 minutes.

4. Screen the magnesium stearate by hand through an 840-microgm screen, and transfer to blender.

5. Mix for 1 minute.

6. Compress using 18-mm standard concave punches.

INGREDIENTSmg/Tablet
CBD Isolate50
Dextrose400
PVP 904
PEG-6000 (powder)6

Pass all ingredients through a 0.8-mm sieve and press with high-compression force.

INGREDIENTSmg/Tablet
CBD Isolate50
Lactose346
Hydroxypropylmethylcellulose 220866
Magnesium stearate3
Colloidal anhydrous silica6
Talc29

1. Mix all ingredients except 4 for 10 minutes.

2. Add Magnesium Stearate and mix for 1 minute.

3.  Compress using low compression forces.

INGREDIENTSmg/Tablet
CBD Isolate50
Lactose200
Microcrystalline Cellulose105
Magnesium Stearate1

A mixture containing CBDC-75, Lactose, and Prosolv 50 is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 355mg tablets

INGREDIENTSmg/Tablet
Sorbitol296
Microcrystalline Cellulose227
B-complex Premix50
Cocoa Powder32
Povidone K3019
Chocolate Flavor6
Magnesium Stearate6
Silicon Dioxide6
Mint Flavor3
Sucralose1

INGREDIENTSmg/Tablet
Clomifen citrate50
Ludipress�100
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 154mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Diclofenac sodium50
Ludipress�150
Magnesium stearate2
Polyethylene glycol (PEG) 6000 powder15
Crospovidone10

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 226mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Diclofenac sodium50
Dicalcium phosphate132
Povidone (PVP K30)6
Ethanol 96%0
Crospovidone10
Magnesium stearate2

1. Mix diclofenac sodium, dicalcium phosphate, and povidone.

2. Granulate diclofenac sodium mixture with ethanol, then pass through a 20 mesh screen.

3. Mix crospovidone and magnesium stearate.

4. Add crospovidone mixture to dry granulated mixture.

5. Compress into 209mg tablets with 8mm bisect convex tooling.

INGREDIENTSmg/Tablet
Diltiazem60
Ludipress�141
Polyethylene glycol 6000 powder5
Silicon dioxide1
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 215mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Dimenhydrinate50
Ludipress�245
Magnesium stearate5

1. Mix all components.

2. Pass through a 20 mesh sieve.

4. Compress into 300mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Hydrochlorothiazide50
Ludipress�280
Magnesium stearate2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 328mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Hydrochlorothiazide50
Lactose Monohydrate422
Povidone (PVP K90)8
2-Propanol38
Crospovidone15
Magnesium stearate2

1. Mix hydrochlorothiazide, lactose monohydrate, and copovidone.

2. Granulate hydrochlorothiazide mixture with propanol, then pass through a 20 mesh screen.

3. Mix crospovidone and magnesium stearate.

4. Add crospovidone mixture to granulated mixture.

5. Compress into 495mg tablets with 12mm bisect tooling.

"
INGREDIENTSmg/Tablet
Indomethacin50
Ludipress�227
Crospovidone20
Magnesium stearate3

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 303mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Indomethacin50
Lactose Monohydrate300
Povidone (PVP K30)10
Water30
Crospovidone12
Silicon dioxide2
Magnesium stearate2

1. Mix indomethacin and lactose monohydrate.

2. Mix povidone and water.

3. Granulate indomethacin mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen.

5. Mix crospovidone, silicon dioxide, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 372mg tablets with 12mm bisect convex tooling.

INGREDIENTSmg/Tablet
Thiamine Hydrocholoride55
Lactose DC290
Magnesium Stearate5
Silicon Dioxide2

INGREDIENTSmg/Tablet
Glutaminic acid573
Sorbitol, crystalline115
Povidone (PVP K30)17
Water0
Crospovidone11
Magnesium stearate2

1. Mix glutaminic acid and sorbitol.

2. Mix povidone and water.

3. Granulate glutaminic acid mixture with povidone solution.

4. Dry then pass through a 20 mesh screen.

5. Mix crospovidone and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 719mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Berberine sulfate6
Ludipress�54
Magnesium stearate1

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 115mg tablets with 6mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate5
Sorbitol DC150
Menthol (crystalline)4
Eucalyptol (crystalline)4
Aspartame, potassium1
Saccharine sodium0
Aerosil 2001
Magnesium stearate1

Mix all components, pass through an 0.8-mm sieve, and press with medium-compression force.

INGREDIENTSmg/Tablet
CBD Isolate5
Mannitol DC93
Gelatin1
Aspartame1
Colloidal silicon Dioxide1

1. Pass item 2 through 0.7-mm sieve and collect in a stainless steel container.

2. Charge half quantity of step 1 in a tumbler.

3. Pass items 1 and items 3 to 5 through 0.5-mm sieve and collect in a container.

4. Add 15% Mannitol from step 1 to step 3 and mix well.

5. Compress at medium force.

INGREDIENTSmg/Tablet
CBD Isolate5
Lactose DC100
Magnesium Stearate2
Aerosil 2001

1. Pass all components through an 0.8-mm sieve, mix, and press with very low-compression force (4 kN).

2. Compress into 202-mg tablets, using 8-mm biplanar punches.

3. This is a very low active ingredient formulation (5 mg), if content uniformity is a problem, prepare a premix of the active ingredient with a small part of the lactose monohydrate before mixing with the other components of the formulation.

INGREDIENTSmg/Tablet
Chlorhexidine5
Sorbitol, crystalline150
Copovidone5
Menthol, crystalline5
Eucalyptol, crystalline5
Aspartame, potassium1
Saccharin, sodium0
Silicon dioxide2
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh mm sieve.

3. Compress into 175mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Folic acid5
Ludipress�195
Magnesium stearate2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 213mg tablets with 8mm bisect tooling.

Note: If the content uniformity does not meet the requirements it would be recommended to prepare a premix of the active ingredient with a small part of Ludipress� or with lactose monohydrate before mixing with the other components of the formulation.

INGREDIENTSmg/Tablet
Glibenclamide5
Ludipress�194
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 201mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Zolmitriptan5
Sodium Starch Glycolate2
Polyethylene Glycol 33503
Chitosan3
Microcrystalline Cellulose6
FlowLac® 100, Spray-dried alpha-lactose monohydrate 60

Active ingredient and all additives are homogeneously blended using geometric dilution after passing through 500 micron screen sieve.

PEG 3350 is added to the mixture.

INGREDIENTSmg/Tablet
Bromocriptine mesylate6
Ludipress�206
Magnesium stearate2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 214mg tablets with 9mm bisect convex tooling.

INGREDIENTSmg/Tablet
Magaldrate700
Lactose Monohydrate435
Povidone (PVP K90)10
Crospovidone50
Magnesium stearate5

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 1200mg tablets with 16mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene70
Lactose DC113
Anhydrous citric acid200
Sodium bicarbonate120
Sodium carbonate12
Sodium cyclamate20
Aspartame15
Orange flavor20
PEG-6000 (powder)30

1. Pass all components through an 0.8-mm sieve and mix. Press with medium- or high-compression force at maximum 30% relative humidity.

3. Use 12-mm biplanar punches for 602-mg tablets.

INGREDIENTSmg/Tablet
Beta-carotene dry powder 10%70
Ludipress�113
Citric acid, anhydrous200
Sodium bicarbonate120
Sodium carbonate12
Sodium cyclamate20
Aspartame15
Orange flavour20
Polyethylene glycol 6000 powder30

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 605mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Sodium chloride884
Copovidone47
Ethanol or Isopropanol0
Caroate884
Crospovidone93
Polyethylene glycol 6000 powder93

1. Mix copovidone with ethanol or isopropanol.

2. Granulate copovidone solution with sodium chloride.

3. Pass mixture through 20 mesh sieve.

4. Dry the granulated mixture.

5. Mix caroate, crospovidone, and polyethylene glycol 6000 powder.

6. Mix caroate mixture with the granulated mixture.

7. Compress into 2000mg tablets with 20mm bisect tooling.

INGREDIENTSmg/Tablet
Bromhexine8
Dicalcium phosphate179
Copovidone7
Crospovidone5
Magnesium stearate1

1. Pass all components through a 20 mesh sieve sieve.

2. Mix then compress into 204mg tablets with size 8mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate8
Lactose Granular24
Microcrystalline cellulose 10140
Povidone24
Sodium starch glycolate22
Magnesium stearate2

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

INGREDIENTSmg/Tablet
Aminophylline, hydrous powder90
Potato starch80
Copovidone6
Water30
Magnesium stearate1
Talc4

1. Mix aminophylline, potato starch, corn starch, and 3g copovidone.

2. Mix 3g copovidone with water.

3. Granulate aminophylline mixture with copovidone solution then pass through a 20 mesh sieve.

4. Dry mixture.

5. Mix magnesium stearate, talc, and polyethylene glycol 6000.

6. Mix magnesium stearate mixture with granulated mixture, then pass through a 35 mesh sieve.

7. Compress into 179mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Atenolol93
Ludipress�287
Magnesium stearate2
Silicon dioxide1

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 436mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
CBD Isolate90
Mannitol DC246
Micrystalline Cellulose30
Aspartame9
Dyes1
Citric Acid1
Flavor2
Magnesium Stearate4

1. The CBDC-75 Granulate is coated with a layer of a taste-masking composition with a thickness of about 3 to 10 micrograms. The coating should be substantially free of cracks, holes, and other imperfections when examined under a scanning electron microscope at 100 to 500 magnification.

2. Charge items 1 to 7 in a suitable blender and mix for 20 minutes.

3. Add item 8 to step 2 and blend for 2 minutes.

4. Compress the appropriate quantity.

INGREDIENTSmg/Tablet
Acetaminophen powder250
Caffeine powder50
Acetysalicylic Acid powder250
Copovidone60
Crospovidone20
Silicon dioxide3
Magnesium stearate4

1. Granulate acetaminophen powder, caffeine powder, acetysalicylic acid powder, and copovidone in a roller compactor.

2. Pass granules through through a 20 mesh sieve with magnesium stearate, silicon dioxide, and crospovidone, then blend for 10 min in VH mixer.

3. Compress into tablets with a force of about 12 kN.

INGREDIENTSmg/Tablet
Albendazole100
Ludipress�288
Magnesium stearate4
Silicon Dioxide8

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 400mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Alginic acid500
Aluminium hydroxide dried gel100
Magnesium trisilicate25
Sodium bicarbonate170
Sorbitol, crystalline160
Sucrose, crystalline627
Ludipress�900
Kollidon VA 6470
Magnesium Stearate50
Vanillin5

1. Pass all components through a 20 mesh sieve.

2. Mix components.

3.Compress into 2000mg tablets with 20mm bisect tooling.

INGREDIENTSmg/Tablet
Freeze dried aloe vera gel150
Sodium starch glycolate25
Mannitol150
Anhydroud lactose q.s to -- mg400

INGREDIENTSmg/Tablet
A. officinalis extract20
Sorbitol280
Polyethylene glycol (PEG) 6000 powder71
Sucrose, crystalline225
Sucrose, powder225
Magnesium stearate5
Colloidal silica dioxide5
Orange flavor22

Prepared by direct compression using a single punch tablet press with 13mm biconvex tooling.

Average weight of each lozenge is about 850mg.

INGREDIENTSmg/Tablet
Aluminum hydroxide200
Magnesium hydroxide200
Lactose monohydrate100
Copovidone30
Water260
Sucrose, crystalline315
Sorbitol, crystalline100
Polyethylene glycol 6000, powder60
Silicon dioxide12
Talc6

1. Mix aluminum hydroxide, magnesium hydroxide, and lactose monohydrate.

2. Mix copovidone and water.

3. Granulate aluminum hydroxide mixture with copovidone solution.

4. Dry the granulated mixture then pass through a 20 mesh sieve.

5. Mix sucrose, sorbitol, polyethylene glycol 6000, silicon dioxide, talc, and magnesium.

6. Mix sucrose mixture with granulated mixture.

7. Compress into 1013mg tablets with 16mm biscect tooling.

INGREDIENTSmg/Tablet
Sucrose576
Aluminium hydroxide157
Magnesium carbonate160
Magnesium oxide97
Povidone (PVP K90)45
Silicon dioxide22
Simethicone, suspension 30%300
Menthol9
Saccharin sodium1
Talc49

1. Mix sucrose, aluminum hydroxide, magnesium carbonate, magnesium oxide, povidone, and silicon dioxide.

2. Granulate mixture with simethicone suspension.

3. Dry the granulated mixture, then sieve through a 20 mesh screen.

4. Mix menthol, saccharin sodium, talc, magnesium stearate.

5. Mix menthol mixture with granulated mixture.

6. Compress into 1295mg tablets with 20mm bisect tooling.

INGREDIENTSmg/Tablet
Aluminium hydroxide dried gel120
Magnesium trisilicate250
Ludipress�232
Silicon dioxide6
Magnesium stearate6
Cyclamate sodium12
Menthol2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 640mg tablets with 16mm bisect tooling.

Note: Due to the poor flowability of the formulation the tabletting machine should be equipped with force feeder.

INGREDIENTSmg/Tablet
Ambroxol hydrochloride30
Ludipress�218
Magnesium stearate3

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 250mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Asprin USP194
Salicylamide USP97
Acetaminophen USP (large crystals or granular)97
Caffeine USP (granular)33
Microcrystalline Cellulose145
Stearic acid powder N. F.12
Cab-O-Sil (Hydrophobic fumed silica)3

1. Blend all the ingredients except microcrystalline cellulose for 20 minutes.

2. Screen in microcrystalline cellulose and blend for an additional 5 minutes.

INGREDIENTSmg/Tablet
Citric acid anhydrous (granular)1180
Sodium bicarbonate1700
Sodium bicarbonate (powder)175
Citrus flavor (spray-dried)50
Water30

1. Thoroughly blend citric acid, sodium bicarbonate (granular), and citrus flavor in a planetary mixer.

2. Quickly add all of water and mix until a workable mass is formed.

3. Granulate through a 10 mesh screen using an oscillating granulator.

4. Spread evenly on a paper-lined drying tray and dry in a convection oven at 70°C for 2 hr.

5. Remove from oven, cool, and regranulate through a 16 mesh screen.

6. Place granulation in a tumble blender and add sodium bicarbonate (powder); Mix well.

7. Compress 25mm flat-faced, beveled edge tablets each weighing 3100mg.

INGREDIENTSmg/Tablet
Acetylsalicylic acid (80-mesh crystals)325
Monobasic calcium phosphate (powder)165
Sodium bicarbonate (granular)1700
Citric acid anhydrous (granular)1060

1. Convert sodium bicarbonate to 7-9% sodium carbonate by placing in a convection oven set at 100°C for 45 minutes, with two mixings at 15 minute intervals.

2. Cool the converted bicarbonate and mix with monobasic calcium phosphate and citric acid in a tumble blender.

3. Add acetylsalicylic acid and mix for 10 minutes.

4. Compress 25mm diameter flat faced, beveled edge tablets each weighing 3250mg.

5. Stabilize tablets in a forced-draft oven at 60°C for 1 hour.

INGREDIENTSmg/Tablet
Asparagus extract, powder200
Parsley extract, powder200
Sorbitol, crystalline200
Copovidone20
Crospovidone10
Magnesium stearate4

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 636mg tablets with 12mm tooling.

INGREDIENTSmg/Tablet
Aspirin USP384
Caffeine USP16
Microcrystalline Cellulose48
Cornstarch N.F.29
Stearic acid N.F.4

Blend all ingredients in a V blender for 20 min.
INGREDIENTSmg/Tablet
Monosodium phosphate anhydrous3200
Citric acid anhydrous (granular)630
Sodium bicarbonate (fine granular)2500
Surfactant17
Blue color1
Simethicone1
Encapsulated fragrance50
Water16

1. Thoroughly mix simethicone with 100g of sodium bicarbonate (fine granular) on which blue color has been previously distributed.

2. Add encapsulated fragrance and mix thoroughly; set aside.

3. Place monosodium phosphate anhydrous in a ribbon blender.

4. Slowly add water while mixing and mix thoroughly.

5. While continuing to mix, slowly add citric acid, anhydrous, 2400g of sodium bicarbonate (fine granular), the sodium bicarbonate /color/simethicone/fragrance premix, and color; Mix well.

6. Compress 25mm diameter flat-faced, beveled edge tablets each weighing 6400mg.

7. Pass through a forced-draft oven to stabilize, cool, and package six tablets to a container.

Note: Six tablets are dissolved in a 25-gallon tub to yield a water softening, lightly colored, and lightly fragranced bath.

INGREDIENTSmg/Tablet
Beta-carotene dry powder 10%100
Ascorbic acid, crystalline250
Sodium ascorbate, crystalline280
Vitamin E acetate dry powder SD 50500
Sorbitol, crystalline600
Ludipress�500
Fructose350
Polyethylene glycol 6000 powder50

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 2600mg tablets with 20mm bisect tooling.

INGREDIENTSmg/Tablet
Calcium Carbonate750
Microcrystalline Cellulose120
Lactose Powder120
EXPLOSOL� (Sodium starch glycolate)8
Sodium lauryl sulfate3

INGREDIENTSmg/Tablet
Calcium lactate USP470
Ac-Di-Sol® (Croscarmellose Sodium)10
Microcrystalline Cellulose80
Stearic acid N.F. (powder)20
Magnesium stearate N.F.4
Celocal® (Co-Processed Cellulose Gel and Calcium Sulfate)116

1. Mix calcium lactate, AcDiCol®, microcrystalline cellulose, and Celocal® for 10 minutes.

2. Add magnesium stearate and blend for an additional 5 minutes.

INGREDIENTSmg/Tablet
Carbonyl iron OF24
Copper sulfate0
Magnsium sulfate4
Ludipress�100
Magnesium stearate2

1. Pass all components through a 35 mesh sieve.

2. Mix sieved components.

4. Compress into 131mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Dried papaya leaf extract3
Lactose Powder4
Mannitol4
Microcrystalline cellulose4

INGREDIENTSmg/Tablet
CBD Isolate30
Sucrose, DC60
Crospovidone XL55
Orange Flavor3
Strawberry Flavor3
Microcrystalline Cellulose 102155
Magnesium Stearate1

Mix all items for 15 minutes, pass through a sieve, add Magnesium Stearate and mix for an additional 1 minute. Press with medium compression force.

INGREDIENTSmg/Tablet
Aluminum Hydroxide (dried gel)320
Magnesium Hydroxide (fine powder)320
Sucrose32
Mannitol288
Povidone0
Glycerin12
Magnesium Stearate19
Fumed Silica6
Peppermint oil0

1. Mix aluminum hydroxide, magnesium hydroxide, sucrose, and mannitol in a suitable blender.

2. Add povidone and glycerin, use this to moisten the mix of the first four ingredients.

3. Granulate by passing through a 14 mesh screen.

4. Dry at 60.00 to 65.56 °C.

5. Size through a 20-mesh screen.

6. Add and thoroughly mix magnesium stearate, fumed silica, and peppermint oil.

INGREDIENTSmg/Tablet
Acetylsalicylic acid USP (crystals)81
Pseudoephedrine hydrochloride30
Fruit flavor (spray-dried)20
Fruit color2
Sodium bicarbonate (granular)550
Citric acid anhydrous (granular)325
Citric acid anhydrous (powder)325

1 Convert sodium bicarbonate (granular) to 7-9% sodium carbonate by placing in a forced-draft (convection) oven at 100°C for 45 minutes with two mixings at 15 minute intervals.

2. Cool the converted bicarbonate and mix with citric acid, anhydrous (granular) and citric acid, anhydrous (powder) in a planetary mixer for 10 minutes.

3. Quickly add water and mix until the water is evenly distributed and a mild reaction occurs.

4. Immediately transfer to paper-lined drying trays and spread evenly. Place trays in a forced-draft oven at 70°C for 2 hours.

5. Remove from oven, cool, and granulate through a 12 mesh screen.

6. Mix together pseudoephedrine hydrochloride, fruit flavor (spray-dried), and fruit color.

7. Mix the dried granulation and pseudoephedrine hydrochloride-flavor-color premix, and acetylsalicylic acid, USP (crystals) in a tumble blender until uniform.

8. Compress 15mm. diameter, flat-faced, beveled edge tablets weighing 1330mg each.

9. Stabilize the tablets by heating in a forced-draft oven at 60°C for 1 hour; Allow to cool.

INGREDIENTSmg/Tablet
Chlorpheniramine maleate USP4
Pseudoephedrine HCI USP60
Microcrystalline Cellulose37
Lactose Powder113
Ac-Di-Sol® (Croscarmellose Sodium)2
CAB-O-SIL® (Hydrophobic fumed silica)1
Stearic acid N.F.1
Magnesium stearate1

1. Screen pseudoephedrine, stearic acid, and magnesium stearate through 40 mesh sieve.

2. Blend chlorpheniramine maleate, pseudoephedrine, and microcrystalline cellulose in V blender for 3 minutes.

3. Add lactose, Ac-Di-Sol&reg, and CAB-O-SIL&reg to step 2 and blend for 17 minutes.

4. Add stearic acid to step 3 and blend for 3 minutes.

5. Add magnesium stearate to step 4 and blend for 5 minutes.

INGREDIENTSmg/Tablet
Aceclofenac100
Chondroitin sulphate50
HPMC (Hydroxypropyl Methylcellulose) K 10025
Microcrystalline cellulose25
Magnesium sterate 3%7
Talc 2%5
Mucilage of starch 7.518

1. Blend all ingredients except for magnesium stearate and talc, then wet granulate with starch mucilage as a binder.

2. Passed wet mass through 16 mesh sieve.

3. Dry granules at 50°C for 2-3 hours.

4. Sieve dried granules through 25 mesh sieve.

5. Lubricate with magnesium stearate and talc mixture.

6. Compress on a 10 station rotary tablet press, using 12mm round convex punches.

INGREDIENTSmg/Tablet
10% DEXTROMETHORPHAN HYDROBROMIDE Adsorbate (micronized)77
Benzocaine3
Mouthwash flavor (Givaudan FS098)10
Magnesium stearate10
Sorbitol (crystalline)1301

*Contains 7. S mg active drug plus 2% excess. Pass the sorbitol through a 10 mesh screen to deagglomerate the particles. Premix the adsorbate, benzocaine, and flavor with one-fourth of the required amount of sorbitol for 10 minutes. Add the rest of the sorbitol and mix for another 10 minutes. Finally, add the magnesium stearate and mix for a further 3 minutes. Compress to a hardness of about 6 kp using S/8-in. diameter tooling. Comments: A noteworthy feature of the above example is that the total drug content (dextromethorphan HBr and benzocaine) of the tablet is about 10mg, which requires a tablet of 1,400mg weight to give satisfactory taste-masking and mouth-feel characteristics. It must also be pointed out that the compression hardness of 6 kp gives the tablet chewable characteristics. Furthermore, the required S/8-in. tooling would put some restriction on the tablet press that could be used for the product.
INGREDIENTSmg/Tablet
Curcumin extract1250
Microcrystalline cellulose270
Croscarmellose sodium60
Magnesium Stearate20

1. Mix microcrystalline cellulose and croscarmellose sodium for 10 minutes in powder mixer.

2. Add curcumin and mix for additional 15 minutes.

3. Add magnesium stearate and mix for 3 minutes.

INGREDIENTSmg/Tablet
Potassium monopersulfate800
Citric acid anhydrous (granular)575
Sodium bicarbonate (granular)800
Sodium chloride320
Sodium perborate monohydrate320
Sodium sulfate225
Polyvinylpyrrolidone100
Isopropyl alcohol170
Sodium lauryl sulfate10
Color2

1. Blend sodium bicarbonate (granular), sodium chloride, sodium perborate monohydrate, sodium sulfate, polyvinylpyrrolidone, in planetary mixer.

2. Add isopropyl alcohol and mix until mass is uniformly wet.

3. Spread wet mixture on trays about 25mm deep.

4. Dry in forced-draft oven at 70°C for 16 hours.

5. Pass dried granulation through an 18 mesh screen using an oscillating granulator.

6. Mix potassium monopersulfate and citric acid, anhydrous (granular) in a tumble blender.

7. Add 1500g of the dried, screened granulation and tumble until well mixed.

8. Distribute sodium lauryl sulfate, color, and oil of peppermint in 265g of the dried, screened granulation and add to the tumble blender; Mix thoroughly.

9. Add magnesium stearate to the tumble blender and mix well.

10. Compress 25mm diameter flat-faced, beveled edge tablets weighing 3190mg each.

INGREDIENTSmg/Tablet
Diethylcarbamazine citrate50
Sodium bicarbonate30
Tartic Acid30
Aspartame2
Sodium lauryl sulfate2
Flavour2
Purified Talc IP2
Treated agar32
Mannitol DC- Food Grade Corn Starch mix (1:1 ratio)50

1. Pass ingredients through 60 mesh sieve individually.

2. Mix diethylcarbamazine citrate and directly compressible excipient by adding a small portion of each at a time and blending until uniform.

3. Preheat sodium bicarbonate and tartic acid at 80 degrees celcius for 2 hours. This removes absorbed or residual moisture.

4. Thoroughly mix sodium bicarbonate and tartic acid in a mortat until uniform, then add to the diethylcarbamazine citrate and excipient mix.

5. Mix remaining ingredients except sodium lauryl sulphate and talc in geometric order inside inflated polyethylene pouch.

6. Add sodium lauryl sulphate and talc, mix for additional 2 minutes.

INGREDIENTSmg/Tablet
Diethylcarbamazine citrate50
Aspartame2
Sodium lauryl sulfate2
Flavour2
Purified Talc IP2
Treated Agar47
Mannitol DC- Food Grade Corn Starch mix (1:1 ratio)95

INGREDIENTSmg/Tablet
Doxylamine succinate USP25
Silicon Dioxide3
Solka Floc BW 100 (Powdered Cellulose)17
Emcompress (Dibasic calcium phosphate)332
Explotab (Sodium Starch Glycolate)20
Magnesium stearate N.F.3

1. Screen magnesium stearate through 30 mesh screen and blend with silicon dioxide for 10 to 15 minutes.

2. Add powdered cellulose and one-third of dibasic calcium phosphate and mix for 10 minutes.

3. Add remaining dibasic calcium phosphate and blend for 10 minutes.

4. Add sodium starch glycolate and blend for 5 to 7 minutes.

5. Add magnesium stearate and blend for 3 to 5 minutes.

INGREDIENTSmg/Tablet
Elderberries e lyophilized extract 10%600
Lactose172
Sucrose DC700
Carbomer G 7118
Magnesium Stearate10

The components of each formulation were weighed, sieved, and mixed for 5 minutes
INGREDIENTSmg/Tablet
Etophylline, powder101
Theophylline, anhydrous 0,2/0,723
Ludipress�53
Magnesium stearate1
Silicon dioxide2

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 175mg tablets with 8mm bisect tooling.

Note: To improve flowability of mixture, increase the amount of silicon dioxide.

INGREDIENTSmg/Tablet
Etophylline, powder100
Theophylline, anhydrous 0.2/0.723
Corn starch or potato starch50
Copovidone7
Water35
Magnesium stearate1
Talc5

1. Mix etophylline, theophylline, starch, and 3g copovidone.

2. Mix 4g copovidone and water.

3. Granulate etophylline mixture with copovidone solution.

4. Pass granulated mixture through 20 mesh sieve then dry.

5. Mix magnesium stearate and talc.

6. Mix granulated mixture with magnesium stearate mixture.

7. Pass mixture through 35 mesh sieve.

8. Compress into 183mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Ferrous sulfate, anhydrous65
Magnese sulfate4
Copper sulfate0
Ludipress�70
Povidone (PVP K30)10
Magnesium stearate2
Silicon dioxide3

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components.

3. Compress into 149mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Sodium bicarbonate (granular)735
Sodium carbonate anhydrous80
Citric acid anhydrous (granular)1300
Aminoacetic acid50
Flavor (spray-dried)50
Color5
Light mineral oil15
Water4

1. Premix light mineral oil with 200g of sodium bicarbonate (granular).

2. Disperse color on 35g of sodium bicarbonate (granular).

3. Place citric acid, anhydrous (granular) in the bowl of a planetary mixer.

4. Start mixer and slowly add water; mix thoroughly.

5. Add to mixer in sequence. While mixing, add the remainder of sodium bicarbonate (granular), sodium carbonate, anhydrous, aminoacetic acid, flavor (spray-dried), the color dispersion, and the mineral oil dispersion; mix until uniform.

6. Compress 19mm flat-faced, beveled edge tablets weighing 2.23g each.

7. Pass through curing oven; Allow to cool.

INGREDIENTSmg/Tablet
Ginger extract250
Microcrystalline cellulose317
Croscarmellose sodium27
Purified Talc6

1. Mix microcrystalline cellulose and croscarmellose sodium for 10 minutes in powder mixer.

2. Add ginger extract and mix for additional 15 minutes.

3. Add purified talc and mix for 3 minutes.

INGREDIENTSmg/Tablet
Mannitol DC545
Guarana dry extract98
Magnesium Stearate8

1. Mix mannitol and guarana for 5 minutes.

2. Add magnesium stearate and mix for 5 minutes.

INGREDIENTSmg/Tablet
Guarana extract200
Microcrystalline cellulose170
Lactose10

INGREDIENTSmg/Tablet
Hydrochlorothiazide50
Potassium chloride300
Crospovidone15
Silicon dioxide2
Magnesium stearate2

1. Pass all components through a 20 mesh sleeve, then mix.

2. Compress into 369mg tablets with 9mm bisect convex tooling.

INGREDIENTSmg/Tablet
Ibuprofen (50 grade)150
Potato starch18
Lactose Monohydrate20
Microcrystalline Cellulose96
Povidone (PVP K30)3
Water52
Croscarmelose2
Magnesium stearate2
Silicon dioxide0

1. Mix ibuprofen, corn starch, lactose monohydrate, and 20g microcrystalline cellulose.

2. Mix povidone with water.

3. Granulate ibuprofen mixture with povidone solution, then pass through 20 mesh sieve.

4. Mix 76g microcrystalline cellulose, croscarmelose, magnesium stearate, and silicon dioxide.

5. Mix sieved mixture with microcrystalline cellulose mixture.

6. Compress into 290mg tablets with 10mm bisect tooling.

Note: Croscarmelose can be substituted for crospovidone.

INGREDIENTSmg/Tablet
Indomethacin100
Lactose Monohydrate369
Povidone (PVP K30)14
Crospovidone14
Magnesium stearate3

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 500mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Inosin200
Lactose Monohydrate51
Povidone (PVP K90)6
Isopropanol60
Crospovidone10
Magnesium stearate3

1. Mix inosin, lactose monohydrate, and povidone.

2. Granulate inosin mixture with isopropanol.

3. Dry granulated mixture then pass through a 20 mesh sieve.

4. Mix crospovidone and magnesium stearate.

5. Mix crospovidone mixture with dry granulated mixture.

6. Compress into 270mg tablets with 9mm bisect convex tooling.

INGREDIENTSmg/Tablet
Dry plant extract (tuberous roots)300
Ethyl cellulose40
Microcrystalline Cellulose40
Dibasic calcium phosphate10
Polyethylene glycol 400010

Note: Extract was created using aqueous extraction with chloroform water solution.

INGREDIENTSmg/Tablet
Isosorbide dinitrate + Lactose (4+6)13
Lactose Monohydrate152
Povidone (PVP K30)5
Crospovidone9
Magnesium stearate1

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 184mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Lactobacillus acidophilus10
Saccharomyces boulardii10
Citric acid15
Sodium bicarbonate15
PVP (Polyvinylpyrrolidone)9
Orange aroma1
Stevia1
Talcum2
Magnesium stearate1
Mannitol26

INGREDIENTSmg/Tablet
Levamisole hydrochloride150
Ludipress�300
Magnesium stearate4

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 458mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Levothyroxine sodium0
Magnesium stearate1
Ludipress�99

1. Mix levothyroxine sodium and magnesium stearate.

2. Add Ludipress® to levothyroxine sodium mixture and pass through 20 mesh sieve.

3. Mix combined mixtures.

4. Compress into 103mg tablets with 6mm bisect tooling.

INGREDIENTSmg/Tablet
Lisinopril10
F-MELT�77
Crosscarmellose sodium5
PVP K302
Sodium carbonate8
Colloidal silica3
Sucralose0
Yellow Iron Oxide0
Peppermint Flavor0
Sodium Stearyl Fumarate3

INGREDIENTSmg/Tablet
Lisinopril10
Ludipress�139
Magnesium stearate1

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress into 152mg tablets with 8mm bisect tooling.

INGREDIENTSmg/Tablet
Sucrose, fine powder (10X Confectioner's sugar)8
Acacia fine powder1
Citric acid fine powder15
10% Gelatin solution0
Menthol12
Benzocaine10
Hexylresorcinol2
Hydrogenated vegetable oil (Sterotex, Duratex)160
Ethanol 95%0

INGREDIENTSmg/Tablet
Metformin500
Crospovidone30
Crosscarmellose sodium30
Microcrystalline cellulose23
Mannitol DC10
Sodium saccharin10
Orange flavor2
Sodium stearyl fumerate1
Talc1

INGREDIENTSmg/Tablet
Mannitol DC585
Mint flavor powder6
Aspartame2
Magnesium Stearate7

1. Mix mannitol, mint flavor, and aspartame for 5 minutes.

2. Add magnesium stearate and mix for 5 minutes.

INGREDIENTSmg/Tablet
Moringa Leaf Powder62
Spirulina Powder27
Microcrystalline Cellulose8
Sodium Carboxymethylcellulose2
Magnesium Stearate2

INGREDIENTSmg/Tablet
Vitamin A acetate dry powder (500,000 i. u./g )5
Vitamin D dry powder (100,000 i. u./g)2
Thiamine mononitrate1
Riboflavin2
Nicotinamide12
Vitamin E acetate dry powder4
Ascorbic acid, powder50
Ferrous fumarate60
Dicalcium phosphate (pre-granulated with 5% Povidone PVP K30)200
Calcium carbonate125

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 500mg tablets with 11mm bisect tooling.

INGREDIENTSmg/Tablet
Vitamin A acetate dry powder (500,000 i. u./g )10
Thiamine mononitrate2
Riboflavin2
Nicotinamide17
Calcium D-pantothenate12
Pyridoxine hydrochloride2
Cyanocobalamin, dry powder 0.1%6
Ascorbic acid, powder85
Vitamin E acetate dry powder31
Ludipress�311

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 500mg tablets with 12mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene dry powder 10%50
Thiamine mononitrate3
Riboflavin3
Pyridoxine hydrochloride3
Nicotinamide22
Calcium D-pantothenate12
Ascorbic acid for direct compression100
Dicalcium phosphate550
Ferrous fumarate80
Magnesium oxide160

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 1205mg tablets with 16mm bisect tooling.

INGREDIENTSmg/Tablet
Beta-carotene Dry Powder 10% CWD23
Vitamin E Acetate 50% Dry Powder40
Thiamine Mononitrate2
Riboflavin Powder2
Nicotinamide22
Calcium D-Pantothenate11
Pyridoxine Hydrochloride2
Cyanocobalomin 0.1% Dry Powder6
Ascorbic Acid, Powder85
Ludipress LCE477
Sodium Bicarbonate600
Tartaric Acid400
Polyethylene Glycol 600090
Orange Flavor60
Aspartame30

INGREDIENTSmg/Tablet
Retinyl Acetate Dry Powder 500,000 I. U./g10
Thiamine Mononitrate2
Riboflavin2
Nicotinamide16
Calcium Pantothenate11
Pyridoxine Hydrochloride2
Cyanocobalamin 0.1% Coated6
Ascorbic Acid, Powder85
Tocopheryl Acetate Dry Powder 50%, Spray-dried31
Ludipress or Avicel PH 101300
Copovidone21
Magnesium Stearate3
Orange Flavor7
Saccharin, Sodium Salt5

INGREDIENTSmg/Tablet
Beta-carotene Dry Powder 10%50
Thiamine Mononitrate3
Riboflavin3
Pyridoxine Hydrochloride3
Nicotinamide22
Calcium D-pantothenate12
Ascorbic Acid for Direct Compression100
Calcium Phosphate, dibasic550
Ferrous Fumarate80
Magnesium Oxide160
Cupric Sulfate2
Manganese Sulfate14
Potassium Chloride50
Zinc Sulfate37
Microcrystalline Cellulose60
Crospovidone50
Stearic Acid6
Magnesium Stearate5

INGREDIENTSmg/Tablet
Nigella sativa L. seed extract10
Silicon Dioxide1
Magnesium stearate1
PVP5
Talc3
Avicel PH 102015
Lactose Powder15
Dextrose0

INGREDIENTSmg/Tablet
Nitroglycerin on lactose (1: 9)20
HPMC (Hydroxypropyl Methylcellulose) E5016
HPMC (Hydroxypropyl Methylcellulose) E4M10
HPC (Hydroxypropyl cellulose)2
Stearic Acid0
Lactose anhydrous spray-dried0

1. Blend cellulose ethers with the lactose.

2. Add nitroglycerin dilution and lubricant; Mix well.

INGREDIENTSmg/Tablet
Nitroglycerin (10% of microcrystalline cellulose)3
Mannitol2
Microcrystalline cellulose29
Flavor0
Sweetner0
Coloring agent0

Screen and blend the powders and compress into tablets.
INGREDIENTSmg/Tablet
Peppermint Oil7
Emdex� Dextrates184
Sorbitol8
Pruv� (Sodium Stearyl Fumarate)2

1. Disperse peppermint oil into Emdex® and blend for 15 minutes.

2. Add sorbitol and mix for 10 minutes.

3. Add Pruv® and mix for 3 minutes.

INGREDIENTSmg/Tablet
Freeze dried pineapple powder50
Citric acid20
Sodium carbonate12
Stevia18

1. Mix powders in a tumbler mixer.

2. Directly compress into 21mm flat face tablets.

INGREDIENTSmg/Tablet
Glycine hydrochloride1338
Potassium chloride597
Potassium bicarbonate1001
Potassium citrate216
Polyvinylpyrrolidone77
Polyethylene glycol 8000 (powder)115
Saccharin20
SiIlea gel (fumed)5
L-Leucine (pulverized)34
Citrus color3

1. Grind together glycine hydrochloride, potassium chloride, potassium bicarbonate, potassium citrate.

2. Mix the ground materials in a tumble blender for 15-20 minutes.

3. Granulate the mixed powders with a solution of polyvinylpyrrolidone, polyethylene glycol 8000 (powder), saccharin dissolved in isopropyl alcohol.

4. Spread the granulation on trays and dry in a forced-air (convection) oven at 50-55°C until the alcohol odor is gone.

5. Pass through a 12 mesh screen.

6. Place granulation in a tumble blender and blend in siliea gel (fumed), citrus flavor (spray-dried), L-Leucine (pulverized).

7. Compress 25mm diameter, flat-faced, beveled edge tablets each weighing 3,410mg.

INGREDIENTSmg/Tablet
Quinidine sulfate USP200
Microcrystalline Cellulose144
CAB-O-SIL® (Hydrophobic fumed silica)2
Stearic acid N.F.9
Magnesium stearate3

1. Blend quinidine sulfate, microcrystalline cellulose, and CAB-O-SIL® for 25 minutes.

2. Screen in stearic acid and magnesium and blend for 5 more minutes.

INGREDIENTSmg/Tablet
Sorbitol DC20
Microcrystalline Cellulose1
Gelatin0
Propylparaben0
Citric Acid0
Mint Extract1
Silicon Dioxide0
Magnesium Stearate0
Salvia officinalis essential oil

Dry excipients are blended, and the dry mix is moistened with an appropriate amount of 4.7% (w/w) microcrystalline cellulose.

The wet mass is passed through sieve number 16.

The granules are dried in a hot air oven at 40 ± 2°C for 2 hours.

The wet granules are re-sieved through number 14 sieve.

1ml of S. officinalis essential oil is mixed with sorbitol and dried in the oven for 1 min at 40 ± 2°C.

Powder containing essential oil is added to dried granules.

The granules are lubricated with 3% (w/w) magnesium stearate.

Mint extract is added as a flavoring agent.

Propylparaben is added as a preservative and antibacterial agent.

INGREDIENTSmg/Tablet
Saw Palmetto extract265
Microcrystalline cellulose704
Croscarmellose sodium26
Purified Talc5

1. Mix microcrystalline cellulose and croscarmellose sodium for 10 minutes in powder mixer.

2. Add saw palmetto and mix for additional 15 minutes.

3. Add purified talc and mix for 3 minutes.

INGREDIENTSmg/Tablet
Senna Concentrate215
Sorbitol5
Hydroxypropyl cellulose10
Lactose Powder30
Croscarmellose sodium14
Hydroxyethyl cellulose10
Silicon dioxide3
Magnesium stearate3

1. Blend all ingredients except magnesium stearate in V mixer at 50 rpm for 50 minutes.

2. Add magnesium stearate and mix for 2.5 minutes.

INGREDIENTSmg/Tablet
Silybum marianum ethanolic extract26
Silicon Dioxide26
MicroceLac® 100 (75% lactose: 25% microcrystalline cellulose)74
Glycolate starch3
Magnesium stearate1

1. Blend extract and excipients (except the magnesium stearate) 10 minutes by tumbling.

2. Add corresponding amount of magnesium stearate and blended for 5 more minutes.

3. Compress into 7mm tablets weighing 130mg each.

Note: Granulate was obtained by immersing the extract in Aeroperl&reg (silicon dioxode) which was used as a carrier in a 1:1 ratio. The evaporation of the solvent was carried out under reduced pressure and then dried in an oven at 40°C to a constant weight.

INGREDIENTSmg/Tablet
Sodium Bicarbonate300
Microcrystalline Cellulose10
Lactose5
Magnesium Stearate3

Prior to blending, pass ingredients through a 20 mesh sieve.
INGREDIENTSmg/Tablet
Spirulina Extract (Powder)250
Firmapress245
Polyethylene glycol (PEG) 6000 powder25
Silicon Dioxide5

1. Mix all components, pass through a 20 mesh sieve.

2. Compress into 495-mg tablets, using 12mm biplanar punches.

INGREDIENTSmg/Tablet
Malic acid420
Sodium bicarbonate290
Sodium carbonate70
Stannous fluoride21
Color3
Flavor20
Sweetener4
Sorbitol110
Polyethylene glycol 8000 (powder)30
Sodium benzoate (fine powder)30

1. Coat sodium benzoate (fine powder) with simethicone in a V blender with auger intensifier bar.

2. Blend malic acid, sodium bicarbonate, sodium carbonate, stannous fluoride, polyethylene glycol 8000 (powder) with the blend of sodium benzoate (fine powder), simethicone, sorbitol, color, sweetener, and flavor in a ribbon blender.

3. Compress 11mm shallow concave 480-500mg each.

INGREDIENTSmg/Tablet
Aspirin500
Mannitol DC432
Stearic acid (< 80 ?m)25
Talc20
Orange flavor, powder15
Aspartame5
Silicon Dioxide3

1. Add aspirin, silicon dioxide, orange flavor, and aspartame to mixer.

2. Mix for 10 minutes.

3. Add talc and mannitol, mix again for 5 minutes.

4. Add stearic acid, mix for 5 minutes.

INGREDIENTSmg/Tablet
Boric acid100
Neomycin sulfate125
Sodium sulfate275
Phenyl mercuric nitrate3

INGREDIENTSmg/Tablet
Sodium bisulfate1200
Sodium bicarbonate250
Detergent30
Color2
Fragrance Oil10

1. Disperse color and fragrance oil on detergent, using geometric dilution techniques.

2. Place 600g of sodium bisulfate in a tumble blender.

3. Add the color/fragrance premix and blend for 1 minute. Add 20g of Detergent and blend for 1 minute.

4. Add 600g of Sodium bisulfate and blend for 2 minutes.

5. Roller-compact or slug the granulaion to densify.

6. Granulate the compacted sheets or slugs by passing through a 12 mesh screen.

7. Place granulation in the tumble blender and add 10g of detergent; Blend thoroughly.

8. Compress on heavy-duty tablet equipment or form compacts using briquetting equipment.

INGREDIENTSmg/Tablet
Sulfathiazole167
Sulfacetamide167
Sulfabenzamide167
Urea400
Lactose400
Guar gum60
Starch30
Magnesium stearate10

1. Finely mill and blend powders.

2. Compress into tablets.

3. Dissolve into sufficient sterile water to make 50ml of solution.

INGREDIENTSmg/Tablet
V. officinalis dry plant extract300
Microcrystalline cellulose146
Lactose Powder146
Magnesium stearate8

1. Blend corresponding dose of V. officinalis dry plant with the selected excipients, except magnesium stearate, for 12 minutes by tumbling.

2. Add 8mg of magnesium stearate and further blended for 4 minutes.

Note: V. officinalis fluid extract was oven-dried with colloidal silicon dioxide as a drying adjuvant.

INGREDIENTSmg/Tablet
Retinyl Acetate or Palmitate Dry Powder 325,000 I. U./g Cold-water-dispersible355
Mannitol350
Copovidone25
Magnesium Stearate5
Silica, Highly Dispersed3

INGREDIENTSmg/Tablet
Retinyl Acetate Dry Powder 500,000 I. U./g163
Microcrystalline Cellulose82
Talc5

INGREDIENTSmg/Tablet
Retinyl Acetate Dry Powder 500,000 I. U./g66
Tocopheryl Acetate Dry Powder 50%, Spray-dried with Gelatin65
Sorbitol, Crystalline425
Polyethylene glycol 6000, Powder15
Orange Flavor15
Cyclamate, Sodium Salt9

INGREDIENTSmg/Tablet
Thiamine Hydrochloride or Thiamine Mononitrate25
Riboflavin25
Nicotinamide80
Calcium Pantothenate40
Pyridoxine Hydrochloride16
Cyanocobalamin 0.1% gelatin-coated16
Microcrystalline Cellulose286
Polyvinylpyrrolidone K3016
Silica, highly dispersed3

INGREDIENTSmg/Tablet
Nicotinamide200
Microcrystalline Cellulose100
Copovidone10
Magnesium Stearate2
Silica, Highly Dispersed2

INGREDIENTSmg/Tablet
Pyridoxine Hydrochloride250
Microcrystalline Cellulose100
Copovidone13
Magnesium Stearate5

INGREDIENTSmg/Tablet
Calcium Carbonate600
Ascorbic Acid1000
Citric Acid1000
Sodium Bicarbonate300
Rutin50
Cholecalciferol Dry Powder 100,000 I. U./g4
Polyethylene Glycol 6000, powder300
Polyvinylpyrrolidone K25 or Copovidone100
Saccharin, Sodium Salt3

© 2019 LFA Machines Oxford LTD. Todos os direitos reservados.