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Tooling Designs – Different Mixes Need Different Punches

Tooling Designs – Different Mixes Need Different Punches

It has always been difficult to market a tablet in the industry today. Aside from time and capital, research and development is also important; that said, one of the most difficult phases is the actual production of the tablet. Plenty of issues arise during production, including tablet quality to downtime of tablet equipment, which can result to delay in shipping of the product. There are steps that one can take to eliminate as well as minimize the issues before manufacturing actually begins.

Different Lubricants Approved For Pharmaceutical Machine Use

Different Lubricants Approved For Pharmaceutical Machine Use

The use of lubricants during manufacturing is crucial as it minimizes the friction between the different parts of the machine. Reducing friction is important as it can cause heating between parts. Adding lubricants also help reduce the tendency of parts to rust and decrease load in the machine.

What is the difference between the TDP 1.5, TDP 5 and the TDP 6s?

What is the difference between the TDP 1.5, TDP 5 and the TDP 6s?

This is a frequently asked question on the TDP range. This range of single station pill press includes the TDP 1.5, TDP 5 and TDP 6s. The machines are very similar and the main distinction between them is the pressure that is exerted during tablet making.

Is A Vegetarian Capsule Much Better than One Made of Gelatin

Is A Vegetarian Capsule Much Better than One Made of Gelatin

Medicines are a go to whenever one experiences health problems. From over the counter medicines to prescriptions, these pills have become vital to our everyday lives. Due to the advancement in technology, two different forms are now available – tablets and capsules. For some time, tablets are quite popular way of taking in medication or supplements; later on however, consumers discover the effects of taking tablets.

Cup Depth Demonstrated On Tablet Press Tooling

​Cup and Tablet - Depth and Consistency

The cup depth is the space between the punch tip and the lowest possible measurable area of a cup cavity. In order to form proper inspection and wear limits of the tooling equipment, it is important that one should know about it, and how premature wear can affect the tablet.

Dial with segments from green to red symbol of risk control or limit

Cool Chain Drugs | What are Cool Chain Drugs?

In the pharmaceutical world, there are certain medicine products that needs certain specific temperature in order to maintain its efficiency, structure and safety.

Healthy everyday nutritional supplement, Vitamin pills and herbal capsules in the bottles

辅酶Q10——为什么应该加入您的产品系列

辅酶Q10(通常简称为CoQ10)是人体自然产生的一种化合物。所有的身体细胞都会产生这种酶,它能加速产生正常细胞维持和生长所需要能量。

Different Types Of Contamination, Causes And Prevention For Pharmaceutical Industry

Different Types Of Contamination, Causes And Prevention For Pharmaceutical Industry

The presence of unwanted materials such as dust and particles during the manufacturing and transportation time is called contamination. The term contaminants includes any unwanted matter that is found in the product. These contaminants affect the quality of the product or the process.

Contaminants Caused By Humans And Methods Of Control

Contaminants Caused By Humans And Methods Of Control

One of the major problems with sterile manufacturing is the possibility of contamination. The cleanroom area is one of the hardest places to maintain sterile or clean and is the major source of contamination.

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Compression Tooling Equipment

Compression Tooling Equipment

Changing the tablet manufacturing process can lead to better and more improved quality products as well as cost efficiency for the company. By communicating with one’s tooling vendor and taking into consideration the right material type, one can overcome the many problems that tablet companies are facing today.

Common Tablet Problems And Solutions

Common Tablet Problems And Solutions

There are varieties of problems that face the pharmaceutical world, some of which we will be discussing as well as solutions that would help solve these problems.

  • Overwetting of the tablets/Surface pitting. This is where suspension droplets hit the still wet tablet and the drying air does not dry it enough.
  • Physical damages overloading or unloading operation.
  • Poor tablet design – flat surfaces.
  • Spray Drying. The suspension droplets hit the tablet after the moisture has been removed. This leads to the poor adherence of the coat
Broken white different size tablets and capsules on a blue background

Common Tablet Defects That Can Be Avoided Easily

Tablet defects occur for a variety of reasons, but many can easily be avoided. To address defects, technicians involved in tabletting must have a full understanding of both the tabletting process and the materials used. Adequate training in the setting up and use of the machines is vital if the technician is to have the necessary skills to be able to fix equipment and minimize problems in production.

Common Problems in Tablet Compression

Common Problems in Tablet Compression

片剂制造行业最常见的问题即为“粘冲”。 当片剂配方中的颗粒粘附于工具端面时则发生粘冲。 这是使用粘性配方或压片失败的结果,或两者兼具的结果。 这对制造商来说问题更严重,因为粘冲在片剂压缩测试中容易忽视,而只有在产品投入生产后才会发现。

Cleaning Agent Used For Pharmaceutical Companies

Cleaning Agent Used For Pharmaceutical Companies

为了保证产品质量,制药业必须使用专用于设备消毒和保护的清洁剂。 虽然我们日常生活中使用的清洁产品多种多样,但制药公司为保证产品质量必须使用专用清洁剂,如非离子洗涤剂。

Checking Your Tooling

Checking Your Tooling

模具和设备必须定期检查和维护,对于片剂生产厂家来说,这是一项必须承担且耗费时间的工作。幸运的是,现在出现了一些机器及相关科技,让包括压片机过程检验和调整等方面的工作变得更加简单。本文将简单介绍一些近期此类新机器及技术,或许能为片剂生产厂家及他们的业务提供一些帮助。

Case Studies in Capsule Filling – Improving Performance, Effectiveness and Productivity

Case Studies in Capsule Filling

本文将介绍Capsugel公司开展的一些案例研究,展示现代医药公司的业绩、效率和生产力如何得到提升。Capsugel公司是的一家国际性的公司,为生物医药、消费保健品、营养品行业的客户设计、研发和生产多种创新剂型。Capsugel公司拥有4000多家企业客户,遍布全球100多个国家。数十年来,Capsugel开发符合客户需求的创新、优质和定制化解决方案,最终让患者及消费者受益。

Capsule Dosage Forms – Hard Gelatin, Soft Gelatin, Modified Release and Enteric

Capsule Dosage Forms – Hard Gelatin, Soft Gelatin, Modified Release and Enteric

胶囊是口服药物和营养品的常用剂型。胶囊的形状、尺寸和材料多种多样,每一个胶囊通常含有单次用量的活性成分。除了活性药物成分或者主要的营养素,胶囊里还含有其他赋形剂作为填充材料,比如抗菌防腐剂、填充剂、香味剂、甜味剂和着色剂等。胶囊外表面可能印着品牌名和药物用量信息。

Breaker Lines - Good or Bad?

Breaker Lines - Good or Bad?

长期以来,制药企业使用片剂刻痕,主要是为了防止脆性断裂断裂,同时也是为了考虑更加美观。二等分刻痕可能对生产商而言是一个挑战,因为它们影响片剂的环带厚度、凹陷深度和预期硬度。随着片剂尺寸增大或改变,二等分刻痕的长度和类型也需要改变。美国医药科学家协会发布的《压片规范手册》(简称TSM),描述了7种片剂刻痕。其中,G型刻痕功能性最强,对手指施加的压力十分敏感,轻轻一掰就能掰断片剂,而H型刻痕功能性最弱,是一种装饰性的刻痕。 

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