Articles Tablet Presses

5 Benefits of Creatine Supplements

5 Benefits of Creatine Supplements

如果你对健康补充剂感兴趣已经有一段时间了,那么你很可能听说过“肌酸”。它是一种常见的健身补充剂,在全球各地的体育和健身用品店就能买到。但你真的知道肌酸都有哪些功效吗?你想知道肌酸对你以及你的客户的健康有哪些作用吗?如果你对此感到好奇,请继续阅读下文。

Close up shot of different types of capsules

An Overview of Encapsulating Liquids

虽然动物明胶胶囊和植物胶囊都能封装溶液,但是封装过程可以说是科学与艺术的结合。在众多的产品中,哪一款产品最好,通常取决于配方的重量和质量。

An Overview Of The Fluidized Bed Dryer

An Overview Of The Fluidized Bed Dryer

流化床干燥机(FBD)广泛应用于制药行业。在制粒过程时,流化床干燥机去除粒状物料的水分。之后,物料进入旋转式压片机进行压片。不同于其他的干燥炉,FBD具有快速干燥的能力,将物料上的水分快速去除至适合压片的水平。

An Overview of Vegetarian Capsules

An Overview of Vegetarian Capsules

The advancement in science and technology makes it easier for one to make their own supplements. Vegetarian capsules are healthier as these are derived from natural ingredients such as cellulose, hydroxyl and methyl. If you are looking for a healthy and natural alternative to traditional capsules, then vegetarian capsules can be an excellent choice for you.

Binder Types and Properties Used in Tablet Manufacturing

Binder Types and Properties Used in Tablet Manufacturing

粘合剂是一种具有粘合能力的化合物,是制作片剂配方时的重要赋形剂。简而言之,粘合剂是提高片剂配方黏性的物质。因此,粘合剂通过制粒这一加工过程将粉料转化成颗粒性物料。在压片行业,制粒指的是将细粉末凝聚成较大颗粒的过程。在凝聚的过程中,粘合剂将活性成分和赋形剂聚集在一起,使颗粒有一定的强度。粘合剂还是颗粒之间连接的纽带,在相邻颗粒之间搭建“桥梁”。这种纽带可能导致粘合剂在压片过程中融化或变软。目前行业内最新的做法是在压片步骤前将干性粘合剂直接加入粉料,而不是将粘合剂加入细粉制成颗粒然后再压片。这种方法也称为直接压片法。制粒使用的粘合剂和直接压片使用的粘合剂不同,下文是两者的介绍。

Breaker Lines - Good or Bad?

Breaker Lines - Good or Bad?

长期以来,制药企业使用片剂刻痕,主要是为了防止脆性断裂断裂,同时也是为了考虑更加美观。二等分刻痕可能对生产商而言是一个挑战,因为它们影响片剂的环带厚度、凹陷深度和预期硬度。随着片剂尺寸增大或改变,二等分刻痕的长度和类型也需要改变。美国医药科学家协会发布的《压片规范手册》(简称TSM),描述了7种片剂刻痕。其中,G型刻痕功能性最强,对手指施加的压力十分敏感,轻轻一掰就能掰断片剂,而H型刻痕功能性最弱,是一种装饰性的刻痕。 

Building strength in to your design

Building strength in to your design

片剂刃边面是狭窄的平面,连接片剂的边缘和弧面,与片剂竖面垂直。片剂应该有刃边面,主要理由如下:

  1. 提高冲模边缘的强度
  2. 减少冲杯内边缘磨损
  3. 减少冲模边缘出现严重刻痕
Capsule Dosage Forms – Hard Gelatin, Soft Gelatin, Modified Release and Enteric

Capsule Dosage Forms – Hard Gelatin, Soft Gelatin, Modified Release and Enteric

胶囊是口服药物和营养品的常用剂型。胶囊的形状、尺寸和材料多种多样,每一个胶囊通常含有单次用量的活性成分。除了活性药物成分或者主要的营养素,胶囊里还含有其他赋形剂作为填充材料,比如抗菌防腐剂、填充剂、香味剂、甜味剂和着色剂等。胶囊外表面可能印着品牌名和药物用量信息。

Case Studies in Capsule Filling – Improving Performance, Effectiveness and Productivity

Case Studies in Capsule Filling

本文将介绍Capsugel公司开展的一些案例研究,展示现代医药公司的业绩、效率和生产力如何得到提升。Capsugel公司是的一家国际性的公司,为生物医药、消费保健品、营养品行业的客户设计、研发和生产多种创新剂型。Capsugel公司拥有4000多家企业客户,遍布全球100多个国家。数十年来,Capsugel开发符合客户需求的创新、优质和定制化解决方案,最终让患者及消费者受益。

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Checking Your Tooling

Checking Your Tooling

模具和设备必须定期检查和维护,对于片剂生产厂家来说,这是一项必须承担且耗费时间的工作。幸运的是,现在出现了一些机器及相关科技,让包括压片机过程检验和调整等方面的工作变得更加简单。本文将简单介绍一些近期此类新机器及技术,或许能为片剂生产厂家及他们的业务提供一些帮助。

Cleaning Agent Used For Pharmaceutical Companies

Cleaning Agent Used For Pharmaceutical Companies

为了保证产品质量,制药业必须使用专用于设备消毒和保护的清洁剂。 虽然我们日常生活中使用的清洁产品多种多样,但制药公司为保证产品质量必须使用专用清洁剂,如非离子洗涤剂。

Common Problems in Tablet Compression

Common Problems in Tablet Compression

片剂制造行业最常见的问题即为“粘冲”。 当片剂配方中的颗粒粘附于工具端面时则发生粘冲。 这是使用粘性配方或压片失败的结果,或两者兼具的结果。 这对制造商来说问题更严重,因为粘冲在片剂压缩测试中容易忽视,而只有在产品投入生产后才会发现。

Broken white different size tablets and capsules on a blue background

Common Tablet Defects That Can Be Avoided Easily

Tablet defects occur for a variety of reasons, but many can easily be avoided. To address defects, technicians involved in tabletting must have a full understanding of both the tabletting process and the materials used. Adequate training in the setting up and use of the machines is vital if the technician is to have the necessary skills to be able to fix equipment and minimize problems in production.

Common Tablet Problems And Solutions

Common Tablet Problems And Solutions

There are varieties of problems that face the pharmaceutical world, some of which we will be discussing as well as solutions that would help solve these problems.

  • Overwetting of the tablets/Surface pitting. This is where suspension droplets hit the still wet tablet and the drying air does not dry it enough.
  • Physical damages overloading or unloading operation.
  • Poor tablet design – flat surfaces.
  • Spray Drying. The suspension droplets hit the tablet after the moisture has been removed. This leads to the poor adherence of the coat
Compression Tooling Equipment

Compression Tooling Equipment

Changing the tablet manufacturing process can lead to better and more improved quality products as well as cost efficiency for the company. By communicating with one’s tooling vendor and taking into consideration the right material type, one can overcome the many problems that tablet companies are facing today.

Contaminants Caused By Humans And Methods Of Control

Contaminants Caused By Humans And Methods Of Control

One of the major problems with sterile manufacturing is the possibility of contamination. The cleanroom area is one of the hardest places to maintain sterile or clean and is the major source of contamination.

Dial with segments from green to red symbol of risk control or limit

Cool Chain Drugs | What are Cool Chain Drugs?

In the pharmaceutical world, there are certain medicine products that needs certain specific temperature in order to maintain its efficiency, structure and safety.

Different Lubricants Approved For Pharmaceutical Machine Use

Different Lubricants Approved For Pharmaceutical Machine Use

The use of lubricants during manufacturing is crucial as it minimizes the friction between the different parts of the machine. Reducing friction is important as it can cause heating between parts. Adding lubricants also help reduce the tendency of parts to rust and decrease load in the machine.

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