磷酸氢钙

from as low as US$ 14.00/kg
SKU
5060477552254
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磷酸二钙是用于生产多种产品的一种原料。在压片或生产胶囊过程中,磷酸二钙是一种“助流剂”.磷酸二钙有多种颗粒规格可选。我们提供的是比较粗级别的磷酸二钙,流动能力好,具有优秀的压缩性。 

流动性是压片过程中的一个重要因素。它能让物料顺利通过机器。使成品的原料始终如一,确保压出来的每一片成品都相同。

“压缩性好”指的是容易从粉末压成固体片剂。LFA的磷酸二钙压缩性非常好。使用磷酸二钙这样的赋形剂能减少搭配新配方的难度。

磷酸二钙极易溶于柠檬酸和柠檬酸铵。pH值为6.5到7。由于它是碱性物质,所以不能和某些酸性原料混用。磷酸二钙的粘合能力一般。需要与其他赋形剂共同发挥作用。 

磷酸二钙容易通过消化系统。它具有多种功能,本身就可作为膳食补充剂。早餐谷物、面粉及面条产品常见到它的身影。磷酸二钙可以吸收少量水分,所以也被作为防结块剂使用。它还是一种矿物质磷来源,在有机食品中广泛使用。磷酸二钙还有一个较大的用途——动物饲料添加剂。它促进动物新陈代谢,加速动物成长与发展。

为保证安全和保护品质,磷酸二钙的使用和储存都需要十分小心。磷酸二钙刺激眼睛,不慎吸入可导致轻松胸闷不适。在使用时,你需要使用佩戴护目镜、手套和防尘口罩。磷酸二钙需要在中等温度下保存。必需暴露于湿润或极端冷热的环境。储存不当可能影响片剂的硬度。 

磷酸二钙是一种非常有效的助留剂,同时为你的配方加入营养。它能作为一种补充剂应用于许多食品,促进人类和动物的健康。消费者饮食中的磷和钙将从多个方面改善身体机能。消费者对它们很熟悉,所以非常适合加入您的片剂中。

LFA提供的磷酸二钙系结晶性粉末,白色或米白色、无味、散粒状。

项目 数值
CAS登录号 7757-93-9或者7789-77-7(二水)
分子式 CaHP
外形 白色粒状粉末
物理形态 固体
储存条件 室温储藏
熔点 分解
密度 2.929 g/cm3 (无水)
2.31 g/cm3 (二水)
分子量 136.06 g/mol (无水)
172.09 (二水)
文件 不耐受数据
技术参数
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Can I produce tablets without Excipients?

It is unlikely that you will be able to produce tablets without using any Excipients at all. Certain products do bind without Excipients, but then do not flow through the machine. We advise that you use our Firmapress ready mix as this works with 99% of products.

What is the difference between the range of excipients?

We offer Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate and Firmapress in our range of excipients.

Microcrystalline Cellulose is a binding agent, which holds the content of the tablet together.

Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed.

Magnesium Stearate is a dry lubricant and helps again with the movement of ingredients through the machine but also helps with the ejection of the tablets from the machine. Please note that Magnesium Sterate does not bind by itself.

Firmapress is an all in one mix of Microcrystalline Cellulose, Magnesium Stearate and Dicalcium Phosphate.

Are your Excipients natural?

Yes, all of our Excipients are extracted from natural sources. For more information please visit the individual product pages.

Can I get a better price for excipients than is listed on the website?

Yes, we have bulk pricing for all of our excipients, and these can be found in this section. We offer bulk in 500 kg, 1 ton, 2 ton and 5 ton lots. The prices are set on these quantities as these are the amounts that will fit on pallets.

How should I clean contact parts that have come into contact with my excipients or active ingredients?

here are 6 steps that should be followed as a general rule of thumb when cleaning contact surfaces that have come into contact with powders:

Dry Clean - First you need to remove as much of the dry powder as possible. You can do this using a hover/vacuum. Make sure that the vacuum you are using has a filter good enough to handle fine dust.

Wet Clean - Next you need to perform a wet clean. This can be done with warm water and soap or if available an ultrasonic cleaner.

Rinse - Next you need to rinse off any soap with potable water (drinking water). You do not have to do this if you used an ultrasonic cleaner in the last step. It is important to ensure that all parts are thoroughly dried immediately after washing to avoid any rusting.

Sanitise - Next you need to sanitise the surface. This step is recommended by the FDA. There are a number of sanitising solutions available designed to be applied and left on.

Lubricate - You now need to lubricate any parts that require it. This should be with the appropriate grade oil or grease considering your use and greasing chart. Store - Finally store any of the parts in a cool dry place. If you are storing them on the machine then make sure the machine is in a temperature controlled environment with low humidity.

How long is the storage period of each excipient? What is the shelf life?

Firmapress - 2 years form batch date.
Dextrose - 3 years from batch date.
Dicalcium Phosphate - 3 years from batch date.
Microcrystalline Cellulose -
Magnesium stearate -
Lactose - 2 years from batch date.
Silica Dioxide - 2 years from batch date.

What kind of condition should excipients be stored in?

Firmapress - 2 years form batch date.
Dextrose - 3 years from batch date.
Dicalcium Phosphate - 3 years from batch date.
Microcrystalline Cellulose -
Magnesium stearate -
Lactose - 2 years from batch date.
Silica Dioxide - 2 years from batch date.

What is the mesh size of your excipients? etc.

Dextrose - approx 100 mesh
Dicalcium Phosphate - approx 100 mesh
Microcrystoline Cellulose - approx 120-200
Magnesium sterate -
Lactose - 80 mesh
Silica Dioxide -
Firmapress - 100-200 mesh

Are all the excipients safe for human consumption?

Yes, all of the excipients are safe for human or animal consumption. There are some precautions that should be taken when handling them and there are some people that might have intolerances to some of them. Information on this can be found in the products MSDS and Intolerance Data Sheet. This can be found in this section for every excipient.

Are all excipients safe for all ages to consume?

Yes, it does not matter what age, size or sex the person consuming the products is. It is, however, important to check the intolerance data.

Can I have a CoA for my Excipient?

Yes. CoA stands for Certificate of Analysis this is also known some times as an MSDS (Material Safety Data Sheet) all of the information contained in a CoA is inside the MSDS for every LFA product which is emailed to you after purchase.

What kind of agent is each excipient?/ What is the main use of each excipient?

Dextrose - Sweetener, binding agent, good for chewable tablets or candy.

Microcrystalline Cellulose - Binder, filling agent. Good at binding tablets and making them bigger. It can also be used as a filler for capsules.

Magnesium stearate - Dry Lubricant. This stops products from getting stuck to the tooling. It can also help with powder flow issues and caking issues.

Lactose - Binder, sweetener and bulking agent. It has a large mesh so it flows well but most people do not like it because of the intolerance issues.

Silica Dioxide - Flowing agent. This assist powders in flowing smoothly through the machines. It also helps with cacking issues where powders get stuck to the machine.

Do any of the excipients increase the speed of damage to tooling? i.e. more granular?

Yes, Dicalcium Phosphate, if used in high amounts, will cause more damage to tooling than just Firmapress or MCC. However, there are not many situations in which this would be a good idea.

Which excipient should I add if the product/API is clumpy?

If your product or API is clumpy then you will need to add an anticaking agent. For this, we recommend silicon dioxide. We only recommend adding a maximum of 2% of this to the mix

Which excipient should I add if the product is sticky?

If your product is sticky then you will need to add a dry lubricant to your mix. For this, we recommend magnesium stearate.

We do not recommend that you add more than 1% to the mix as more than this can cause capping. If your product is still sticky at this point then we would recommend looking into granulation.

Which excipient should I add if the product doesn't bind well?

If your product does not bind well then we would recommend using MCC. This can be used in any % the limiting factor is the size of the tablet.

If the amount of MCC you would have to use would be too much or if you do not want to use MCC then you have 3 other options: Ask your supplier for a directly compressible or tabletable grade of your product. Spray dry your product. Wet granulate your product.

Dissolving rate? Any known factors that can affect the rate, speed up or slow down the breakdown of a tablet?

Yes. There are two things at play here. You can get hygroscopic and hydrophobic excipients. Hygroscopic means that they take on water quickly, while hydrophobic means that they repel water.

There are products know as supper disintegrants. These products help the breakdown of tablets. At the moment LFA does not sell any supper disintegrants.

Magnesium stearate is hydrophobic this means that it will slow the breakdown of a tablet.

However, it is used in such small amounts that most of the time it will not make a difference to our customer's products. If they would like to be sure then they should conduct what is known as a disintegration test.

Are there any known allergens or health risks?

Yes, there are all of them can be found in the intolerance sheets for each product. The intolerance sheets can be found here: https://www.lfatabletpresses.com/product-data

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