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リン酸二カルシウム

Starting from $39.99
SKU
5060477552254

価格は税込みです

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リン酸二カルシウムは、さまざまな製品の成分になっています。「流動化剤」として錠剤やカプセルの製造で使用されています。リン酸二カルシウムは、さまざまなメッシュサイズがあります。こちらで提供される粗い等級は、流動性が良く優れた圧縮性があります。

流動性は製造プロセスの重要な要素です。成分が機械を通りやすくするようにします。つまり、最終製品が隅々まで成分が安定するということです。これは各錠剤が同じ品質になることを確かなものにします。

圧縮率は、粉体を硬い錠剤にしやすくします。LFAのリン酸二カルシウムは、直接圧縮できます。リン酸二カルシウムのような賦形剤を使用すると、新たな成分を生むのに要する努力を軽減します。

リン酸二カルシウムは、クエン酸やクエン酸アンモニアで非常に溶解しやすいです。塩基性度は6.5~7.0pHです。そのアルカリ度により、酸性の有効成分に働きかけません。リン酸二カルシウムの結合特性は中程度です。他の賦形剤に加える必要があるでしょう。

リン酸二カルシウムは、容易に消化系を通っていきます。多種多様な用途があり、それ自体が栄養補助食品です。よく朝食のシリアル、小麦粉や麺に入っています。水分を少量吸収できるので、老化防止物質として使用されます。また、しばしば有機食事療法で用いられるミネラルのリン供給源になります。リン酸二カルシウムの他の顕著な使用はペットフードです。動物の代謝に貢献し、成長や育成を促します。

リン酸二カルシウムに適切な取り扱いは、製品の安全や品質の面で重要です。本製品は目を刺激する可能性があり、息を吸うと胸部の不快感を生じさせる恐れがあります。取り扱う際、目を保護するもの(ゴーグルやサングラスなど)や吸入マスクを使用してください。リン酸二カルシウムを適温で常に密封容器に入れて保管してください。不適切な保管は、時間をかけて錠剤の硬度に影響を与える可能性があります。

リン酸二カルシウムは、成分への栄養で貢献する有効な流動化剤です。人間や動物の健康へ貢献するサプリメントとして多くの食品に添加されています。消費者の食事に対するリン酸及びカルシウムは、多くの面で身体機能を改善するでしょう。これは消費者が使いやすく、お客様の錠剤を完璧な添加物にする優れた製品です。

LFAのリン酸二カルシウムは、結晶状粉末として届きます。カラーは白色またはオフホワイトで流動性に優れています。

名称
CAS番号 7757-93-9 or 7789-77-7 (二水和物)
分子式 CaHP
外観 白色の粒状粉末
物理的状態 固形
保管方法 室温で保管
融点 分解する
密度 2.929 g/cm3 (無水)
2.31 g/cm3 (二水和物)
分子量 136.06 g/mol (無水)
172.09 (二水和物)
資料 不耐データ
技術仕様書
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What is the difference between the range of excipients?

We offer Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate and Firmapress in our range of excipients.

Microcrystalline Cellulose is a binding agent, which holds the content of the tablet together.

Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed.

Magnesium Stearate is a dry lubricant and helps again with the movement of ingredients through the machine but also helps with the ejection of the tablets from the machine. Please note that Magnesium Sterate does not bind by itself.

Firmapress is an all in one mix of Microcrystalline Cellulose, Magnesium Stearate and Dicalcium Phosphate.

Can I produce tablets without Excipients?

It is unlikely that you will be able to produce tablets without using any Excipients at all. Certain products do bind without Excipients, but then do not flow through the machine. We advise that you use our Firmapress ready mix as this works with 99% of products.

Are your Excipients natural?

Yes, all of our Excipients are extracted from natural sources. For more information please visit the individual product pages.

Can I get a better price than is listed on the website?

Yes, we have bulk pricing for all of our excipients and it can be found in this section. We offer bulk in 500kg, 1 ton, 2 ton and 5 ton lots. The prices are set on these quantities as it is the amounts that will fit on pallets.

Firmapress
Weight Price £ Price $ Price €
500kg 5,808.23 7,500.00 6,632.40
1 Ton 10,842.02 14,000.00 12,380.48
2 Ton 20,135.18 26,000.00 22,992.32
5 Ton 46,465.80 60,000.00 53,059.20

Microcrystalline Cellulose
Weight Price £ Price $ Price €
500kg 2,230.36 2,880.00 2,546.84
1 Ton 3,568.57 4,608.00 4,074.95
2 Ton 6,245.00 8,064.00 7,131.16
5 Ton 14,497.33 18,720.00 16,554.47

Dicalcium Phosphate
Weight Price £ Price $ Price €
500kg 1,626.30 2,100.00 1,857.07
1 Ton 2,602.08 3,360.00 2,971.32
2 Ton 4,553.65 5,880.00 5,199.80
5 Ton 10,570.97 13,650.00 12,070.97

Magnesium Stearate
Weight Price £ Price $ Price €
500kg 1,053.22 1,360.00 1,202.68
1 Ton 1,685.16 2,176.00 1,924.28
2 Ton 2,949.03 3,808.00 3,367.49
5 Ton 6,845.96 8,840.00 7,817.39

Silicon Dioxide
Weight Price £ Price $ Price €
500kg 3,670.80 4,740.00 4,191.68
1 Ton 5,873.28 7,584.00 6,706.68
2 Ton 10,278.23 13,272.00 11,736.70
5 Ton 23,860.19 30,810.00 27,245.90

Lactose Powder
Weight Price £ Price $ Price €
500kg 3,330.05 4,300.00 3,802.58
1 Ton 5,328.08 6,880.00 6,084.12
2 Ton 9,324.14 12,040.00 10,647.21
5 Ton 21,645.32 27,950.00 24,716.74

Dextrose Monohydrate
Weight Price £ Price $ Price €
500kg 1,115.18 1,440.00 1,273.42
1 Ton 1,784.29 2,304.00 2,037.47
2 Ton 3,122.50 4,032.00 3,565.58
5 Ton 7,248.66 9,360.00 8,277.24

How should I clean contact parts that have come into contact with my excipients or active ingredients?

here are 6 steps that should be followed as a general rule of thumb when cleaning contact surfaces that have come into contact with powders:

Dry Clean - First you need to remove as much of the dry powder as possible. You can do this using a hover/vacuum. Make sure that the vacuum you are using has a filter good enough to handle fine dust.

Wet Clean - Next you need to perform a wet clean. This can be done with warm water and soap or if available an ultrasonic cleaner.

Rinse - Next you need to rinse off any soap with potable water (drinking water). You do not have to do this if you used an ultrasonic cleaner in the last step. It is important to ensure that all parts are thoroughly dried immediately after washing to avoid any rusting.

Sanitise - Next you need to sanitise the surface. This step is recommended by the FDA. There are a number of sanitising solutions available designed to be applied and left on.

Lubricate - You now need to lubricate any parts that require it. This should be with the appropriate grade oil or grease considering your use and greasing chart. Store - Finally store any of the parts in a cool dry place. If you are storing them on the machine then make sure the machine is in a temperature controlled environment with low humidity.

How long is the storage period of each excipient? What is the shelf life?

Firmapress - 2 years form batch date.
Dextrose - 3 years from batch date.
Dicalcium Phosphate - 3 years from batch date.
Microcrystalline Cellulose -
Magnesium stearate -
Lactose - 2 years from batch date.
Silica Dioxide - 2 years from batch date.

What kind of condition should excipients be stored in?

Firmapress - 2 years form batch date.
Dextrose - 3 years from batch date.
Dicalcium Phosphate - 3 years from batch date.
Microcrystalline Cellulose -
Magnesium stearate -
Lactose - 2 years from batch date.
Silica Dioxide - 2 years from batch date.

What is the mesh size of your excipients? etc.

Dextrose - approx 100 mesh
Dicalcium Phosphate - approx 100 mesh
Microcrystoline Cellulose - approx 120-200
Magnesium sterate -
Lactose - 80 mesh
Silica Dioxide -
Firmapress - 100-200 mesh

Are all the excipients safe for human consumption?

Yes, all of the excipients are safe for human or animal consumption. There are some precautions that should be taken when handling them and there are some people that might have intolerances to some of them. Information on this can be found in the products MSDS and Intolerance Data Sheet. This can be found in this section for every excipient.

Are all excipients safe for all ages to consume?

Yes, it does not matter what age, size or sex the person is consuming the products. It is, however, important to check the intolerance data.

Can I have a CoA for my Excipient?

Yes. CoA stands for Certificate of Analysis this is also known some times as an MSDS (Material Safety Data Sheet) all of the information contained in a CoA is inside the MSDS for every LFA product which is emailed to you after purchase.

What kind of agent is each excipient?/ What is the main use of each excipient?

Dextrose - Sweetener, binding agent, good for chewable tablets or candy.

Microcrystalline Cellulose - Binder, filling agent. Good at binding tablets and making them bigger. It can also be used as a filler for capsules.

Magnesium stearate - Dry Lubricant. This stops products from getting stuck to the tooling. It can also help with powder flow issues and caking issues.

Lactose - Binder, sweetener and bulking agent. It has a large mesh so it flows well but most people do not like it because of the intolerance issues.

Silica Dioxide - Flowing agent. This assist powders in flowing smoothly through the machines. It also helps with cacking issues where powders get stuck to the machine.

Do any of the excipients increase the speed of damage to tooling? i.e. more granular?

Yes, Dicalcium Phosphate, if used in high amounts, will cause more damage to tooling than just Firmapress or MCC. However, there are not many situations in which this would be a good idea.

Which excipient should I add if the product/API is clumpy?

If your product or API is clumpy then you will need to add an anticaking agent. For this, we recommend silicon dioxide. We only recommend adding a maximum of 2% of this to the mix

Which excipient should I add if the product is sticky?

If your product is sticky then you will need to add a dry lubricant to your mix. For this, we recommend magnesium stearate.

We do not recommend that you add more than 1% to the mix as more than this can cause capping. If your product is still sticky at this point then we would recommend looking into granulation.

Which excipient should I add if the product doesn't bind well?

If your product does not bind well then we would recommend using MCC. This can be used in any % the limiting factor is the size of the tablet.

If the amount of MCC you would have to use would be too much or if you do not want to use MCC then you have 3 other options: Ask your supplier for a directly compressible or tabletable grade of your product. Spray dry your product. Wet granulate your product.

Dissolving rate? Any known factors that can affect the rate, speed up or slow down the breakdown of a tablet?

Yes. There are two things at play here. You can get hygroscopic and hydrophobic excipients. Hygroscopic means that they take on water quickly, while hydrophobic means that they repel water.

There are products know as supper disintegrants. These products help the breakdown of tablets. At the moment LFA does not sell any supper disintegrants.

Magnesium stearate is hydrophobic this means that it will slow the breakdown of a tablet.

However, it is used in such small amounts that most of the time it will not make a difference to our customer's products. If they would like to be sure then they should conduct what is known as a disintegration test.

Are there any known allergens or health risks?

Yes, there are all of them can be found in the intolerance sheets for each product. The intolerance sheets can be found here: https://www.lfatabletpresses.com/product-data

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