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Articles sur l'enrobage des comprimés

Multiple Station Tablet Rotary Press

Multiple Station Tablet Rotary Press

There are 2 types of tablet presses: single-punch and rotary tablet presses. Most high speed tablet presses take the form of a rotating turret that holds any number of punches and dies. As they rotate around the turret, the punches come into contact with cams which control the vertical position of each punch. Tablets produced by a rotary tablet press are compressed into uniform size, shape and weight making it the preferred machine for large-scale manufacture as it also produces more tablets than single punch machines.

Octagonal Blender – Operation and Cleaning Guide

Octagonal Blender – Operation and Cleaning Guide

A quick guide to learning how to operate and clean the Octagonal Blender used in the tablet manufacturing industry.

Overview Of Lyophilization Of Pharmaceutical Products

Overview Of Lyophilization Of Pharmaceutical Products

There are different products that are classified as parenteral and as some are unstable in solution form, they are being lyophilized. The process helps increase the shelf life of these products. In this article we look at how to best achieve this.

Overview Of The Film Coating Process And Difference Between Solvent And Aqueous Coating

Overview Of The Film Coating Process And Difference Between Solvent And Aqueous Coating

A single stage process, which results in quicker production. Minimal weight gain of tablets is at 2 – 3% compared with sugar coating which adds 60 to 80%. The film coat will not likely affect the tablet’s disintegration process.

One benefit of film coating is that it is easy to automate making it easier to comply with GMP requirements for Standard Operating Policy. It holds the ability to maintain its shape and allows for embossing.

how a tdp 5 grew a supplement company

Oxford Vitality - The Birth & Growth Of A Supplement Company

Over the years at LFA Tablet Presses we have seen our fair share of supplement companies but one of our biggest success by far is Oxford Vitality.

Pharmaceutical User Requirement Specification Of Equipment

Pharmaceutical User Requirement Specification Of Equipment

The URS or User Requirement Specification is a document that contains buyer’s requirements concerning the equipment that they would like to purchase. The Equipment User Department prepares the URS and then sends it to the equipment manufacturer to follow. There are some points to consider when making the URS for pharmaceutical companies.

Preventing Cross Contamination In Pharmaceutical Production Process

Preventing Cross Contamination In Pharmaceutical Production Process

There are several ways to prevent cross contamination during production and below are some ways to do so. Before starting, line clearance should be performed as per the SOP of the company. Do a checklist and record. Check to see if any starting materials are missing, previous record documents, product residues and product itself. Practice a closed system when handling the materials.

Procedure for Moving Desktop Tablet Presses

Procedure for Moving Desktop Tablet Presses

1) Ensure that anyone moving the press is wearing the correct protective clothing. This may include:

  • Steel toe boots
  • Heavy duty grip gloves
  • Back support belt
Procedures To Follow During In Process, Off-line and On-line Packing

Procedures To Follow During In Process, Off-line and On-line Packing

In this short article we state the guidelines to follow during the online and offline packing for pharmaceutical companies.

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Process For Gowning – Entry And Exit Change Rooms

Process For Gowning – Entry And Exit Change Rooms

To prevent any contamination to the processing area or inside the building, it is important to learn the procedure for changing clothes during entry and exit through the company’s changing areas.

Color-coding can identify the personnel and their department. Color-coding for the first change room and primary change room is as indicated below:

Production – Standard Operating Procedures

Production – Standard Operating Procedures

A standard operating procedure (SOP) is a written instruction describing how a routine task is to be carried out; when, where and by whom. SOPs play a fundamental role in continuous quality assurance and ensuring best practice for your company, in order to assist you in protecting the safety of your patients and members of the public. The implementation of SOPs, which are specific to your production facility, will help you to:

Protection beyond the packaging (how to keep moisture out of tablets)

Protection beyond the packaging (how to keep moisture out of tablets)

There are many factors to be considered in the quest for drug quality assurance.These include environmental moisture, stability and packaging solutions.If all of these aspects are addressed throughout the manufacturing and storage processes, the product can be isolated and protected from all possible threats to quality and efficacy.

Rapid Mix Granulator – Operation and Cleaning Guide

Rapid Mix Granulator – Operation and Cleaning Guide

A rapid mix granulator is a multi-purpose mixer/processor equally suitable for high speed dispersion of dry powders (including effervescent powders) and their granulation with aqueous or organic solvents. The equipment is designed to achieve rapid mixing and the formation of consistent granules required for the production of high quality pharmaceutical tablets for solid dosage forms of medication. Good mixing and control of granule size leads to fast tableting speeds and high quality products with low rejection rate.

Risk Of Mix Up And Cross Contamination

Risk Of Mix Up And Cross Contamination

A Mix–Up may be defined as:

  • An unplanned combination of various compounds.
  • A mistake brought about wrongly identifying one material for another.

A mix-up can be caused by bad judgement or lack of attention to detail, i.e., human error. It can also occur though poor communication between personnel.

Tablet Press Efficiency At Batch Sizes

Rotary Tablet Press Efficiency Per Batch Size

A big factor in choosing your Rotary Tablet Press will be the batch sizes you intend to produce with it.

While it might seem that the machine with the most output should finish every batch size in first, the table below demonstrates that is not the case.

The larger the machine the more parts there are to clean meaning the higher the labour costs.

Broken white tablets

Solutions For Tablet Sticking

One of the major problems that the tablet manufacturing companies faces is tablet sticking. This problem occurs when the granulation sticks to the punch surface causing deformed tablets, which is very costly not only for the manufacturers but also for the formulators. One way to alleviate this problem is using analytical method as well as create screening processes. Authorities or field experts are also looking for ways to create analytical models to identify the solutions quickly for specific problems.

Tablet Binders what you need to know

Tablet Binders

Tablet binders are one of the most essential elements in the formulation of a tablet. Because they promote cohesiveness, the binders, also called adhesives, help the other ingredients in a tablet to mix together. Tablet binders are used to turn powder to granules; this is achieved through the process of granulation. During granulation, powder substances are accumulated to form larger particles called granules.

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