In wet granulation, powders are bound together using adhesives rather than compacting motion. As more liquid is added to the mix, bridges form between the particles, which increase the tensile strength of bonds.
The process of wet granulation includes the massing of mix dry powders with granulating fluid. The fluid contains solvent, which can easily be removed when dried. The fluid should be non-toxic and may include water, isopropanol, ethanol and methylene; they can be used alone or combined with other solvents.
The dry granulation process is a process whereby granules are formed without the aid of any liquid solution, as the ingredient to be granulated is moisture- or heat-sensitive. To form these granules, it is important to use compacting and to densify the powder. A slugging tool or a roller compactor tablet press machine is used to conduct the dry granulation process.
While some dosage forms are effective if released immediately into the blood stream, in many cases it is advantageous to either release the active ingredient slowly or target the release to a specific area of the body. An active ingredient or formulation that dissolves slowly in the body fluids may achieve a sustained release but it may also be affected by food and the local pH of the surrounding fluids. In addition, it may be necessary for the drug to pass through the low pH stomach fluids and be released at higher pH in the intestinal tract. Controlled release of active ingredient from orally administered tablets is normally achieved by applying an enteric coating to the surface of the tablet.
Binders are chemical compounds that have an adhesive property. They bind the drug and excipient together and provide it with extra strength. Binders can also form intergranular bonds that fuse together and form a binder bridge between granules adhering to each other. The bridges may result from the melting or softening of the binder during the compression process.
Although LFA Tablet Presses does not sell capsules or capsule fillers we do feel that it is very important to provide our customers with as much information as possible. In this article we discuss the types of capsules and the their potential applications.
Terminal sterilization is the process of sterilizing sterile pharmaceutical products. Small and volume parenteral after the packing of the final products. This process is important as it ensures the sterility of the product.
There are different products that are classified as parenteral and as some are unstable in solution form, they are being lyophilized. The process helps increase the shelf life of these products. In this article we look at how to best achieve this.
In the pharmaceutical manufacturing process, it is important that blend uniformity be achieved. If there is poor uniformity, the product can be rejected based on weight or punch pressure causing loss of revenue to the your business. In this article we talk about how to overcome this problem.
One of the major problems with sterile manufacturing is the possibility of contamination. The cleanroom area is one of the hardest places to maintain sterile or clean and is the major source of contamination.