Definition: The term is used when either the upper or lower part of the tablet separates horizontally either partially away from the main body or completely and forms a cap when ejected from the press or during the handling process.
Cause: This happens when air is trapped during the compression stage and when the tablet expands after being ejected from the die.
Tablet binders are one of the most essential elements when it comes to the tablet's formulation. The binders, also called as adhesives are the ingredients
that aid the other ingredients to mix together as they promote cohesiveness. Through granulation, the powder is turned into granules. Granulation is a process where powder substances are accumulated to form larger particles called as granules.
Description: Double Impression includes punches that embed monograms or images on tablets.
Cause: During the impression stage, each tablet undergoes imprinting. In the said stage, engraving machines imprint on the tablet; with the double imprinting, the lower punch might be uncontrolled and drops freely the short distance causing a new imprint on the tablet producing the double imprint on the tablet.
Description: The term “Binding” is used when the tablet sticks to, takes hold or splits during the molding / pressing process.
During the process, a film is built on the molding or die area restraining the ejection of the tablet. If there is excessive binding, the sides of the tablet might cracked or crumble.
Cause: Binding usually occurs when there is little or lack of lubrication, too much moisture in the granules used and using worn out or old dies.
The ability of an active ingredient to be absorbed by the body depends on its bioavailability, which is affected by the active ingredients solubility and absorbency as it passes the gastrointestinal membrane and is subjected to the gastrointestinal fluid. The ability to be absorbed depends on several physical and chemical composition of the drug. That said, the rate in which drugs dissolves depends on the tablet’s disintegration.